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Table 2 Caffeine-induced contractures with and without preincubation by cyclopiazonic acid 25 μM (CPA); median and quartile; * p < 0.05 for differences with CPA and without CPA.

From: Inhibition of sarcoplasmic Ca2+-ATPase increases caffeine- and halothane-induced contractures in muscle bundles of malignant hyperthermia susceptible and healthy individuals

Caffeine [mM]

0.5

1

1.5

2

3

4

32

MHS [mN]

1 (0 – 1)

1 (1 – 1)

3 (1 – 6)

8 (4 – 12)

20 (15 – 31)

21 (14 – 35)

171 (136 – 137)

MHS CPA [mN]

3 (2 – 8)*

14 (11 – 31)*

27 (17 – 47)*

32 (25 – 38)*

31 (27 – 37)

34 (29 – 38)

131 (108 – 191)

MHEh [mN]

1 (1 – 2)

1 (1 – 1)

0 (0 – 0)

1 (0 – 1)

2 (1 – 3)

4 (3 – 7)

127 (108 – 190)

MHEh CPA [mN]

0 (0 – 1)

3 (0 – 5)

7 (3 – 19)*

12 (11 – 27)*

31 (29 – 37)*

46 (31 – 47)*

199 (156 – 227)

MHN [mN]

1 (0 – 1)

1 (0 – 1)

1 (1 – 1)

1 (0 – 1)

1 (0 – 1)

1 (0 – 2)

158 (108 – 176)

MHN CPA [mN]

2 (1 – 2)

2 (1 – 2)

1 (1 – 5)

1 (1 – 6)

4 (1 – 21)*

17 (4 – 27)*

167 (153 – 180)