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Figure 12 | BMC Anesthesiology

Figure 12

From: Human physiologically based pharmacokinetic model for propofol

Figure 12

Comparison of NONMEM (Schnider et. al., Table 2 [20]) and PBPK model predictions for a standard male (21% body fat, age 53, weight 77 kg and height 177 cm). The top row shows the model predictions for a 1-hour constant infusion of 100 μg/kg/min followed by a 9 hour washout (left, absolute plot; right, semi-log plot). The middle row shows the model predictions when the washout period is extended to 49 hours. The bottom row compares the model predictions for a 5 day constant infusion of 100 μg/kg/min.

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