TY - JOUR AU - Scheinichen, Dirk AU - Elsner, Holger-Andreas AU - Osorio, Rodin AU - Jüttner, Björn AU - Gröschel, Werner AU - Jaeger, Karsten AU - Piepenbrock, Siegfried PY - 2004 DA - 2004/04/23 TI - Lack of influence of the COX inhibitors metamizol and diclofenac on platelet GPIIb/IIIa and P-selectin expression in vitro JO - BMC Anesthesiology SP - 4 VL - 4 IS - 1 AB - The effect of non-steroidal anti-inflammatory drugs (NSAIDs) for reduced platelet aggregation and thromboxane A2 synthesis has been well documented. However, the influence on platelet function is not fully explained. Aim of this study was to examine the influence of the COX-1 inhibiting NSAIDs, diclofenac and metamizol on platelet activation and leukocyte-platelet complexes, in vitro. Surface expression of GPIIb/IIIa and P-selectin on platelets, and the percentage of platelet-leukocyte complexes were investigated. SN - 1471-2253 UR - https://doi.org/10.1186/1471-2253-4-4 DO - 10.1186/1471-2253-4-4 ID - Scheinichen2004 ER -