Table 1 Trials details
From: Individual patient meta-analysis of single-dose rofecoxib in postoperative pain
Trial ID | Pain condition | Study drug and dose, number of patients | Design | Observations after 8 hrs | Quality, Validity scores |
|---|---|---|---|---|---|
27 | Dental | Rofecoxib 50 mg, 38 Naproxen 550 mg, 39 Placebo, 39 | Single oral dose, parallel | 12, 24 | Q 5 V 16 |
51 | Dental | Rofecoxib 50 mg, 72 Naproxen 550 mg, 49 Placebo, 48 | Single oral dose, parallel | 12, 24 | Q 5 V 16 |
66 | Dental | Rofecoxib 50 mg, 50 Ibuprofen 400 mg, 51 Placebo, 50 | Single oral dose, parallel | 12, 24 | Q 5 V 16 |
71 | Dental | Rofecoxib 50 mg, 50 Ibuprofen 400 mg, 52 Placebo, 50 | Single oral dose, parallel | 12, 24 | Q 5 V 16 |
84 | Dental | Rofecoxib 50 mg, 56 Ibuprofen 400 mg, 56 Placebo, 56 | Single oral dose, parallel | 12, 24 | Q 5 V 16 |
95 | Dental | Rofecoxib 50 mg, 90 Ibuprofen 400 mg, 46 Placebo, 45 | Single oral dose, parallel | 10, 12, 24 | Q 5 V 16 |
104 | Dental | Rofecoxib 50 mg, 151 Ibuprofen 400 mg, 46 Placebo, 45 | Single oral dose, parallel | 10, 12, 24 | Q 5 V 16 |
111 | Dental | Rofecoxib 50 mg, 159 Ibuprofen 400 mg, 53 Placebo, 52 | Single oral dose, parallel | 10, 12, 24 | Q 5 V 16 |
127 | Dental | Rofecoxib 50 mg, 180 Paracetamol 600 mg + Codeine 60 mg, 180 Placebo, 30 | Single oral dose, parallel | 12, 24 | Q 5 V 16 |
128 | Dental | Rofecoxib 50 mg, 182 Paracetamol 600 mg + Codeine 60 mg, 180 Placebo, 31 | Single oral dose, parallel | 12, 24 | Q 5 V 16 |
152 | Dental | Rofecoxib 50 mg, 90 Oxycodone 5 mg + Paracetamol 325 mg, 91 Placebo, 31 | Single oral dose, parallel | 12, 24 | Q 5 V 16 |
154 | Dental | Rofecoxib 50 mg, 91 Oxycodone 5 mg + Paracetamol 325 mg, 89 Placebo, 30 | Single oral dose, parallel | 12, 24 | Q 5 V 16 |
169 | Dental | Rofecoxib 50 mg, 121 Diclofenac 50 mg Q8 hr, 121 Placebo, 63 | Single oral dose, parallel | 10, 11, 12, 16, 20, 24 | Q 5 V 16 |
72 | Postsurgical | Rofecoxib 50 mg, 110 Naproxen 550 mg, 55 Placebo, 53 | Multiple with single dose efficacy data, AE 5 days, parallel | 12 hrs | Q 5 V 16 |