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Table 5 Effect of covariate analysis on variance ( ω 2 ) of Clearance

From: Covariates of intravenous paracetamol pharmacokinetics in adults

Sequential nested model

PPVt2

BSVR2

BOV2

PPVP2

PPVP2/PPVt2

No covariates

0.19

0.19

0

0

0

Allometric scaling (TBW)

0.19*

0.10

0.0413

0.0487

0.256

Allometric scaling (NFM)

0.19*

0.0889

0.0557

0.0454

0.239

F AGECL

0.19*

0.0799

0.0557

0.0544

0.286

F PREGCL

0.19*

0.0803

0.0513

0.0584

0.3074

F ABDCL

0.19*

0.0605

0.0533

0.0762

0.401

  1. * = assumed from no covariate model estimate.
  2. [PPV = population parameter variability; BSV = between subject variability; BOV = between occasion variability; TBW = total body weight; NFM = normal fat mass; preg = pregnant, abd = abdominal surgery; IC = intensive care patients; ortho = orthopaedic surgery].