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Table 1 Summary data of the pooled studies

From: Covariates of intravenous paracetamol pharmacokinetics in adults

Reference

ref 8

ref 9

ref 11

ref 10

ref 12

ref 13

ref 11

ref 11

Ref 11

Characteristics

12 healthy males

12 healthy males

8 healthy females

Orthopaedic surgery

High dependency and IC, 38 cases

Abdominal surgery

Caesarean delivery

Postpartum early

Postpartum late,

14 healthy females

 

40 cases

20 cases

41 cases

8 cases (15 weeks)

7 cases (1 year)

Study design

Single iv bolus, 0.5 g

iv loading dose 2 g,

single iv bolus, 2 g

Single iv bolus, 1 g

Single iv bolus, 1 g

repeated 1 g, 6 qh

iv loading dose 2 g, maintenance 1 g q6h

iv loading 2 g

iv loading 2 g

Maintenance 1 g q6h

48–72 h

Weight

63-83 kg

49-94 kg

54-74 kg

58-107 kg

53-120 kg

57-101 kg

57-110 kg

52-88 kg

50-87 kg

Age

21-25 years

19-34 years

27-37 years

20-88 years

34-82 years

44-85 years

31, SD 5.8 years

31, SD 5.8 years

32, SD 6 years

Sampling strategy

13 samples/case

32 samples/case

4 samples/case

20 samples/case

8 samples/case

2x9 samples/case

4 samples after loading dose + up to 24 h

4 samples/case

4 samples/case,

up to 24 h

up to 48 h

up to 6 h

up to 24 h

up to 6 h

up to 72 h

up to 6 h

up to 6 h

Analytical technique

HPLC-uv

HPLC-uv

HPLC-uv

HPLC

Fluorescent polarization immuno-assay

HPLC

HPLC-uv

HPLC-uv

HPLC-uv

LLOQ

< 0.1 μg/ml

< 0.02 μg/ml

< 0.08 μg/ml

< 0.25 μg/ml

< 0.2 μg/ml

n.a.

< 0.08 μg/ml

< 0.08 μg/ml

< 0.08 μg/ml

CV%

<6.4%

< 3%

< 15%

< 12.8%

< 7.5%

n.a.

< 15%

< 15%

< 15%

  1. [IC = intensive care; iv = intravenous; SD = standard deviation, HPLC = High Pressure Liquid Chromatography; LLQ = lower limit of quantification; CV = coefficients of variation].
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BMC Anesthesiology

ISSN: 1471-2253

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