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Table 1 Summary data of the pooled studies

From: Covariates of intravenous paracetamol pharmacokinetics in adults

Reference ref 8 ref 9 ref 11 ref 10 ref 12 ref 13 ref 11 ref 11 Ref 11
Characteristics 12 healthy males 12 healthy males 8 healthy females Orthopaedic surgery High dependency and IC, 38 cases Abdominal surgery Caesarean delivery Postpartum early Postpartum late,
14 healthy females   40 cases 20 cases 41 cases 8 cases (15 weeks) 7 cases (1 year)
Study design Single iv bolus, 0.5 g iv loading dose 2 g, single iv bolus, 2 g Single iv bolus, 1 g Single iv bolus, 1 g repeated 1 g, 6 qh iv loading dose 2 g, maintenance 1 g q6h iv loading 2 g iv loading 2 g
Maintenance 1 g q6h 48–72 h
Weight 63-83 kg 49-94 kg 54-74 kg 58-107 kg 53-120 kg 57-101 kg 57-110 kg 52-88 kg 50-87 kg
Age 21-25 years 19-34 years 27-37 years 20-88 years 34-82 years 44-85 years 31, SD 5.8 years 31, SD 5.8 years 32, SD 6 years
Sampling strategy 13 samples/case 32 samples/case 4 samples/case 20 samples/case 8 samples/case 2x9 samples/case 4 samples after loading dose + up to 24 h 4 samples/case 4 samples/case,
up to 24 h up to 48 h up to 6 h up to 24 h up to 6 h up to 72 h up to 6 h up to 6 h
Analytical technique HPLC-uv HPLC-uv HPLC-uv HPLC Fluorescent polarization immuno-assay HPLC HPLC-uv HPLC-uv HPLC-uv
LLOQ < 0.1 μg/ml < 0.02 μg/ml < 0.08 μg/ml < 0.25 μg/ml < 0.2 μg/ml n.a. < 0.08 μg/ml < 0.08 μg/ml < 0.08 μg/ml
CV% <6.4% < 3% < 15% < 12.8% < 7.5% n.a. < 15% < 15% < 15%
  1. [IC = intensive care; iv = intravenous; SD = standard deviation, HPLC = High Pressure Liquid Chromatography; LLQ = lower limit of quantification; CV = coefficients of variation].
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BMC Anesthesiology

ISSN: 1471-2253

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