Sugammadex is effective in reversing rocuronium in the presence of antibiotics

BMC Anesthesiology

Table 3 Summary of times to recovery of the TOF ratio to 0.9 following administration of sugammadex ≥15 min after the last dose of rocuronium (analyzed by antibiotic administration and NMB depth for patients with data available for the number of twitches at the start of sugammadex administration)

Antibiotics	No. of twitches	n	Geometric mean recovery time (min)	95% confidence interval
No	0	60	2.4	2.0–2.7
No	≥1	51	1.6	1.4–1.9
No		111 ^†	2.0	1.8–2.2
Yes	0	24	2.2	1.7–2.8
Yes	≥1	33	1.3	1.2–1.5
Yes		57 ^†	1.6	1.4–1.9

NMB: neuromuscular blockade; TOF: train-of-four.
^†Nine patients (three patients who received antibiotics and six who did not) had data available for recovery to a TOF ratio of ≥0.9, but no data regarding the depth of NMB (number of twitches) at the time of sugammadex administration.
The text in bold indicates the sub-totals of antibiotics or no antibiotics, irrespective of the NMB depth.

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