The role of plasma gelsolin in cardiopulmonary bypass induced acute lung injury in infants and young children: a pilot study

Table 2 Perioperative changes of plasma gelsolin and total protein levels

	Total	ALI (n = 27)	Non-ALI (n = 50)	p
Before CPB (a)
TP (g/L)	62.4 ± 5.6	59.3 ± 5.6	64.1 ± 4.8	0.01^a
pGSN (mg/L)	157.8 ± 52.8	122.6 ± 24.6	176.4 ± 54.5	0.01^a
pGSN_N (10⁻³)	2.51 ± 0.84	2.02 ± 0.39	2.77 ± 0.89	0.01^a
After CPB (b)
TP (g/L)	55.1 ± 4.6	55.3 ± 4.9	55.0 ± 4.7	0.81^a
pGSN (mg/L)	138.7 ± 51.9	133.2 ± 54.0	141.7 ± 51.2	0.53^a
pGSN_N (10⁻³)	2.52 ± 0.92	2.41 ± 0.95	2.33 ± 0.98	0.11^a
2 hours after CPB (c)
TP (g/L)	56.6 ± 5.2	54.9 ± 4.9	57.5 ± 5.1	0.08^a
pGSN (mg/L)	152.0 ± 73.7	142.9 ± 66.9	156.8 ± 77.6	0.65^a
pGSN_N (10⁻³)	2.33(1.26 ~ 0.76)	2.62 ± 1.24	2.747 ± 1.35	0.23^a
6 hours after CPB (d)
TP (g/L)	56.9 ± 5.8	55.6 ± 6.6	57.6 ± 4.9	0.22^a
pGSN (mg/L)	124.3 ± 47.8	89.9 ± 17.6	141.0 ± 49.0	0.01^a
pGSN_N (10⁻³)	1.80(1.15 ~ 4.63)	1.61 ± 0.26	2.18 ± 0.75	0.04^a
12 hours after CPB (e)
TP (g/L)	58.0 ± 4.6	55.7 ± 3.7	59.1 ± 4.7	0.01^a
pGSN (mg/L)	135.9 ± 54.0	121.3 ± 38.3	142.5 ± 59.1	0.33^a
pGSN_N (10⁻³)	2.34 ± 0.91	2.19 ± 0.73	2.41 ± 0.98	0.40^a
24 hours after CPB (f)
TP (g/L)	58.1 ± 5.4	57.7 ± 4.8	58.3 ± 5.7	0.71^a
pGSN (mg/L)	124.6 ± 43.9	133.0 ± 58.2	121.0 ± 36.5	0.37^a
pGSN_N (10⁻³)	2.16 ± 0.75	2.31 ± 0.87	2.09 ± 0.69	0.98^a
48 hours after CPB (g)
TP (g/L)	60.1 ± 5.8	61.3 ± 5.3	60.4 ± 6.2	0.61^a
pGSN (mg/L)	123.1 ± 39.8	111.7 ± 27.0	129.5 ± 44.6	0.14^a
pGSN_N (10⁻³)	2.05 ± 0.74	1.80 ± 0.45	2.19 ± 0.83	0.33^a
72 hours after CPB (h)
TP (g/L)	64.4 ± 7.2	66.2 ± 7.7	63.1 ± 6.6	0.18^a
pGSN (mg/L)	131.2 ± 39.6	124.6 ± 37.8	136.4 ± 41.3	0.33^a
pGSN_N (10⁻³)	2.02 ± 0.63	1.92 ± 0.55	2.08 ± 0.67	0.31^a

Data were expressed as the mean ± SD or median (interquartile range) if appropriated.
^a: ANCOVA.
TP = plasma total protein amount; pGSN = plasma gelsolin; pGSN_N = plasma gelsolin normalized by plasma total protein amount.

ISSN: 1471-2253