Nasal high–flow oxygen therapy in patients with hypoxic respiratory failure: effect on functional and subjective respiratory parameters compared to conventional oxygen therapy and non-invasive ventilation (NIV)

Table 2 Measured variables

	Bl 1	Bl 2	Bl 3	VM	HFNC	NIV	p-value
HR [1/min]	90 ± 23	90 ± 23	89 ± 20	87 ± 21	89 ± 23	86 ± 21	ns
BP_mean [mmHg]	88 ± 16	90 ± 15	86 ± 18	88 ± 13	90 ± 16	91 ± 18	ns
RR [1/min]	28 ± 9	28 ± 9	26 ± 7	28 ± 8*	26 ± 7	24 ± 9*	*VM – NIV
RR [1/min]	28 ± 9	28 ± 9	26 ± 7	28 ± 8*	26 ± 7	24 ± 9*	p < 0,01
SpO₂ [%]	93 ± 3	92 ± 6	93 ± 3	95 ± 4	96 ± 3	98 ± 3	ns
pH	7.47 ± 0.06	7.46 ± 0.05	7.46 ± 0.07	7.46 ± 0.06	7.46 ± 0.07	7.44 ± 0.08	ns
PaO2 [mmHg]	67 ± 15	64 ± 10	66 ± 10	85 ± 22^#	101 ± 34*^†#	129 ± 38^†*	^#VM-HFNC
							p < 0,01
							^†HFNC-NIV
							p < 0,01
							*VM-NIV-
							p < 0,001
PaCO2 [mmHg]	36 ± 5	38 ± 5	37 ± 5	37 ± 6	37 ± 5	39 ± 7	ns
Borg scale	3.6 ± 2.5	4.3 ± 3.2	3.9 ± 2.7	3.3 ± 2.3	2.9 ± 2.1*	5.0 ± 3.3*	*HFNC-NIV
Borg scale	3.6 ± 2.5	4.3 ± 3.2	3.9 ± 2.7	3.3 ± 2.3	2.9 ± 2.1*	5.0 ± 3.3*	p < 0,05
Patient comfort	2.5 ± 1.6	4.0 ± 1.9	4.0 ± 2.3	3.1 ± 2.8	2.7 ± 1.8*	5.4 ± 3.1*	*HFNC-NIV
Patient comfort	2.5 ± 1.6	4.0 ± 1.9	4.0 ± 2.3	3.1 ± 2.8	2.7 ± 1.8*	5.4 ± 3.1*	p < 0,05
Global rating	n. a.	n. a.	n. a.	3.1 ± 1.7*	2.3 ± 1.3#	4.5 ± 1.7#*	*VM-NIV
							p < 0,05
							^#HFNC-NIV
							p < 0,01

Values are presented as means ± standard deviation, Bl baseline, VM Venturi mask, NIV Non-invasive ventilation, HFNC nasal high-flow oxygen, HR heart rate, BP _mean mean arterial blood pressure, RR respiratory rate, SpO ₂ peripheral oxygen saturation, PaO2 arterial pressure of oxygen, PaCO2 arterial partial pressure of carbon dioxide.

ISSN: 1471-2253