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Table 1 Additional parameters and MMIMS-MIGET-derived V/Q over six hours

From: TIP peptide inhalation in experimental acute lung injury: effect of repetitive dosage and different synthetic variants

 

SD-TIP-A

RD-TIP-A

SD-TIP-B

Parameter

Baseline

3 h

6 h

Baseline

3 h

6 h

Baseline

3 h

6 h

AaDO2 [kPa]

64.7 (4.3)

50.4 (10.3)

49.6 (8.8)

66.4 (6.3)

50.9 (20.3)

45.1 (17.5)

71.3 (11.5)

52.4 (14.0)

42.5 (14.3)

PaCO2 [kPa]

6.7 (1.0)

5.1 (2.3)

5.5 (0.7)

7.5 (2.5)

6.5 (0.5)

6.0 (0.8)

7.2 (1.0)

6.1 (0.7)

5.7 (0.5)

Shunt [%]

35 (7)

20 (2)

25 (7)

28 (8)

20 (3)

19 (9)

33 (15)

19 (7)

20 (6)

Low V/Q [%]

0 (2)

6 (15)

0 (3)

3 (6)

0.1 (7.5)

0 (0)

0 (0)

5 (15)

0 (0)

Normal V/Q [%]

62 (8)

70 (11)

72 (5)

67 (6)

74 (13)

79 (8)

65 (11)

72 (17)

79 (6)

High V/Q [%]

0.7 (0.2)

0.6 (0.3)

0.6 (0.9)

0.7 (0.8)

0.7 (0.4)

1.0 (0.8)

0.6 (1.1)

0.7 (0.8)

0.5 (1.5)

Vt [ml kg-1]

9.8 (0.2)

10.1 (0.5)

9.9 (0.6)

10.2 (0.6)

10.3 (0.7)

10.1 (0.5)

9.7 (0.2)

9.9 (0.6)

9.8 (0.8)

Ppeak [cmH2O]

20 (4)

20 (4)

19 (5)

20 (6)

20 (11)

19 (8)

19 (4)

23 (8)

19 (7)

PEEP [cmH2O]

0.5 (0.1)

0.6 (0.7)

0.6 (0.2)

0.5 (0.2)

0.6 (0.6)

0.6 (0.5)

0.6 (0.2)

0.6 (0.3)

0.6 (0.3)

RR [min-1]

30 (4)

28 (5)

30 (5)

30 (4)

30 (4)

30 (3)

30 (6)

30 (3)

29 (5)

Cdyn [ml mbar-1]

13 (3)

13 (3)

13 (4)

13(3)

13 (4)

13 (4)

14 (3)

13 (4)

11 (5)

Raw [mbar s l-1]

8 (1)

8 (2)

8 (1)

8 (2)

9 (3)

9 (3)

7 (1)

7 (2)

8 (2)

MAP [mmHg]

100 (6)

93 (15)

87 (19)

102 (25)

92 (14)

91 (11)

89 (11)

85 (18)

80 (15)

MPAP [mmHg]

30 (5)

27 (4)

26 (6)

35 (6)

31 (5)

30 (7)

31 (7)

29 (12)

26 (14)

CO [l min-1]

3.8 (1.0)

3.5 (1.2)

3.3 (0.9)

3.8 (0.9)

3.6 (0.7)

3.5 (0.5)

3.7 (1.2)

3.6 (0.6)

3.3 (0.9)

PVR [dyn s cm-5]

423 (127)

384 (152)

432 (368)

362 (122)

395 (137)

436 (120)

392 (199)

333 (252)

411 (355)

HR [min-1]

100 (25)

97 (18)

96 (23)

109 (36)

92 (39)

96 (36)

114 (27)

100 (33)

100 (23)

PCWP [mmHg]

13 (5)

12 (6)

13 (7)

14 (5)

13 (4)

13 (6)

12 (2)

12 (5)

12 (5)

CVP [mmHg]

11 (1)

10 (2)

10 (2)

12 (2)

11 (4)

10 (4)

10 (1)

10 (1)

10 (1)

  1. Data are expressed as median (IQR). No relevant intergroup differences were found. AaDO 2 : Alveolar-arterial oxygen gradient; PaCO 2 : Arterial partial pressure of oxygen; Shunt and V/Q measured by MMIMS-MIGET; V t : Tidal volume; P peak : Peak inspiratory pressure; PEEP: Positive end-expiratory pressure; RR: Respiratory rate; FiO 2 : Fraction of inspired oxygen; C dyn : Dynamic compliance; R aw : Airway resistance; MAP: Mean arterial pressure; MPAP: Mean pulmonary arterial pressure; CO: Cardiac output; PVR: Pulmonary vascular resistance; HR: Heart rate; PCWP: Pulmonary capillary wedge pressure; CVP: Central venous pressure.
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BMC Anesthesiology

ISSN: 1471-2253

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