Pharmacokinetics of tramadol after subcutaneous administration in a critically ill population and in a healthy cohort

Table 1 Demographic and clinical details of patients and healthy subjects

Demographic and clinical details		Patients n = 15	Healthy subjects n = 8
Age (years)		43 (20–65)*	25 (19–51)
Gender	Male	13	8
Gender	Female	2	0
Weight (kg)		75 (72–76)	74 (60–97)
APACHE II score †		7 (2–14)	Not applicable
Admission Diagnosis (n)		Multi-trauma (10)	Not applicable
Admission Diagnosis (n)		Orthopedic surgery (1)	Not applicable
		Gastrointestinal surgery (4)

All patients and healthy subjects received 50 mg subcutaneous bolus dose of tramadol. Data are shown as median (range) *p = 0.006 † Acute Physiological and Chronic Health Evaluation.

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