Table 5 Multivariable logistic regression analysis to determine independent predictors of hospital mortality

Continuous renal replacement therapy within 48 hours

5.52

1.94-16.34

0.001

Intra-abdominal source of infection

3.92

1.47-10.79

0.006

Escherichia coli infection

0.34

0.11-0.90

0.029

APACHE III score, per unit increase

0.99

0.98-1.01

0.323

Vasopressor for at least 1 hour

1.77

0.77-4.21

0.181

Lactate, per 1 mmol/L increase

0.98

0.84-1.13

0.736

Do not resuscitate in case of cardiac arrest

1.95

0.86-4.40

0.109

Full adherence to non-antimicrobial elements of the sepsis bundle

0.83

0.38-1.81

0.646

Median time to appropriate antimicrobial therapy, per hour delay

0.98

0.87-1.15

0.769

Enrolled after sepsis response team implementation at study ICU

1.21

0.57-2.72

0.618

Urinary source of infection

0.72

0.26-1.88

0.506

Staphylococcus aureus infection

2.34

0.95-5.83

0.064

Received metronidazole

2.79

0.99-7.88

0.053