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Table 4 Muscular carbon dioxide partial pressure (PCO 2 ) of malignant hyperthermia susceptible (MHS) and non-susceptible (MHN) pigs following succinylcholine or halothane or succinylcholine and halothane application

From: The effect of succinylcholine on malignant hyperthermia events in susceptible swine

Diagnose

Muscular PCO2[mmHg] t = 0 min

t = 15 min

t = 30 min

t = 45 min

MHSSCh (n = 9)

60 [45–64]

59 [45–62]

73 [65–87]*#

78 [69–92]*#

MHNSCh (n = 10)

54 [41–59]

55 [46–60]

56 [47–59]

58 [50–60]

MHSHalothane (n = 6)

54 [51–58]

54 [50–57]

59 [57–71]

106 [101–120]*#

MHNHalothane (n = 10)

59 [48–63]

58 [49–62]

54 [48–63]

56 [48–60]

MHSHalothane+SCh (n = 12)

56 [48–60]

56 [47–66]

114 [56–167]

140+

MHNHalothane+SCh (n = 10)

56 [54–65]

56 [47–66]

56 [55–65]

58 [56–68]

  1. t = 0 minutes: Baseline values; t = 15 minutes: Application of 4 mg/kg succinylcholine or 0.5 vol% halothane or both; t = 30 minutes: Application of 4 mg/kg succinylcholine or 1 vol% halothane or both.
  2. SCh = succinylcholine.
  3. Data as median and interquartile range;
  4. *significant changes from baseline values; #significant differences between MHS and MHN; p < 0.05. +: data from only one MHS animal.