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Table 2 Arterial blood gas samples of malignant hyperthermia susceptible (MHS) and non-susceptible (MHN) pigs following succinylcholine or halothane or succinylcholine and halothane application

From: The effect of succinylcholine on malignant hyperthermia events in susceptible swine

Diagnose

Time [min|

pH

PaO2[mmHg]

PaCO2[mmHg]

BE [mmol/l]

Lactate [mM]

MHSSCh (n = 9)

0 min

7,38 [7,36-7,44]

260 [242–285]

40 [38–43]

0,5 [−1,7-1,2]

0,5 [0,4-0,7]

15 min

7,39 [7,37-7,44]

282 [263–298]#

40 [38–42]

0,0 [−1,7-1,2]

0,5 [0,4-0,6]

30 min

7,21 [7,11-7,22]*#

243 [194–269]

59 [55–66]*#

−4,6 [−9,2- -3,6]*#

2,7 [2,2,3,2]*#

 

45 min

7,19 [7,11-7,23]*#

240 [229–255]

64 [57–72]*#

−3,7 [−9,2- -3,6]*#

1,5 [1,2-1,8]*#

MHNSCh (n = 10)

0 min

7,42 [7,37-7,45]

246 [187–274]

42 [39–43]

2,0 [−0,2-2,6]

0,7 [0,5-0,9]

15 min

7,42 [7,37-7,43]

249 [197–266]

42 [40–45]

1,8 [−0,4-2,5]

0,6 [0,5-0,7]

30 min

7,40 [7,36-7,44]

233 [183–271]

43 [39–46]

2,7 [0,3-3,0]

0,6 [0,5-1,0]

 

45 min

7,39 [7,36-7,44]

253 [198–268]

44 [39–46]

1,4 [−0,4-2,4]

0,6 [0,5-0,7]

MHSHalothane (n = 6)

0 min

7,38 [7,34-7,39]

260 [257–270]

40 [39–41]

−1,2 [−2,5- -0,4]

0,6 [0,5-0,7]

15 min

7,39 [7,36-7,42]

265 [257–265]

39 [38–40]

−0,2 [−1,5-0,4]

0,5 [0,4-0,6]

30 min

7,29 [7,19-7,38]

254 [248–259]

48 [41–52]

−3,2 [−8,9- -0,4]

2,4 [1,7-5,1]

 

45 min

7,03 [6,99-7,09]*#

212 [192–247]

67 [58–77]*#

−12,3 [−15,1- -10,8]*#

9,0 [8,2-9,9]*#

MHNHalothane (n = 10)

0 min

7,39 [7,35-7,42]

247 [201–279]

43 [39–46]

0,5 [−1,5-1,1]

0,6 [0,5-0,8]

15 min

7,38 [7,33-7,42]

249 [195–276]

43 [39-46|

0,0 [−1,8-0,9]

0,8 [0,6-1,0]

30 min

7,39 [7,35-7,49]

238 [200–253]

42 [38–46]

−0,3 [−2,2-0,8]

0,9 [0,5-1,1]

 

45 min

7,39 [7,34-7,40]

232 [179–259]*

40 [39–44]

−1,0 [−2,6-0,6]

0,6 [0,5-1,0]

MHSHalothane+SCh (n = 12)

0 min

7,47 [7,41-7,51]

256 [250–281]

36 [32–37]

2,4 [0,3-4,6]

1,1 [0,9-1,4]

15 min

7,42 [7,33-7,44]*

261 [247–271]

39 [38–44]*

0,1 [−2,6-2,1]

3,1 [1,6-3,6]

30 min

6,90 [6,83-7,13]*#

256 [194–314]#

69 [33–87]*#

−18,6 [−23,3- -15,0]*#

15,7 [15,3-21,4]*#

 

45 min

6,69+

247+

42+

−34,1+

29,5+

MHNHalothane+SCh (n = 10)

0 min

7,41 [7,41-7,48]

262 [242–291]

36 [35–38]

1,0 [−1,9-3,3]

1,1 [0,9-1,4]

15 min

7,44 [7,37-7,46]

243 [231–274]

37 [36–41]

0,3 [−21-2,8]

1,1 [0,9-1,4]

30 min

7,38 [7,35-7,44]

238 [216–274]

37 [36–38]

−0,4 [−3,6-1,5]

1,3 [1,0-1,4]

 

45 min

7,37 [7,34-7,43]

239 [205–253]*

39 [37–40]

−2,3 [−4,7- -0,5]

1,2 [1,1-1,3]

  1. t = 0 minutes: Baseline values; t = 15 minutes: Application of 4 mg/kg succinylcholine or 0.5 Vol% halothane or both; t = 30 minutes: Application of 4 mg/kg succinylcholine or 1 Vol% halothane or both.
  2. SCh = succinylcholine; PaO2 = arterial oxygen partial pressure; PaCO2 = arterial carbon dioxide partial pressure; BE = base access.
  3. Data as median and interquartile range.
  4. *significant changes from baseline values; #significant differences between MHS and MHN; p < 0.05. +: data from only one MHS animal.