From: The effect of succinylcholine on malignant hyperthermia events in susceptible swine
Diagnose | Time [min| | pH | PaO2[mmHg] | PaCO2[mmHg] | BE [mmol/l] | Lactate [mM] |
---|---|---|---|---|---|---|
MHSSCh (n = 9) | 0 min | 7,38 [7,36-7,44] | 260 [242–285] | 40 [38–43] | 0,5 [−1,7-1,2] | 0,5 [0,4-0,7] |
15 min | 7,39 [7,37-7,44] | 282 [263–298]# | 40 [38–42] | 0,0 [−1,7-1,2] | 0,5 [0,4-0,6] | |
30 min | 7,21 [7,11-7,22]*# | 243 [194–269] | 59 [55–66]*# | −4,6 [−9,2- -3,6]*# | 2,7 [2,2,3,2]*# | |
45 min | 7,19 [7,11-7,23]*# | 240 [229–255] | 64 [57–72]*# | −3,7 [−9,2- -3,6]*# | 1,5 [1,2-1,8]*# | |
MHNSCh (n = 10) | 0 min | 7,42 [7,37-7,45] | 246 [187–274] | 42 [39–43] | 2,0 [−0,2-2,6] | 0,7 [0,5-0,9] |
15 min | 7,42 [7,37-7,43] | 249 [197–266] | 42 [40–45] | 1,8 [−0,4-2,5] | 0,6 [0,5-0,7] | |
30 min | 7,40 [7,36-7,44] | 233 [183–271] | 43 [39–46] | 2,7 [0,3-3,0] | 0,6 [0,5-1,0] | |
45 min | 7,39 [7,36-7,44] | 253 [198–268] | 44 [39–46] | 1,4 [−0,4-2,4] | 0,6 [0,5-0,7] | |
MHSHalothane (n = 6) | 0 min | 7,38 [7,34-7,39] | 260 [257–270] | 40 [39–41] | −1,2 [−2,5- -0,4] | 0,6 [0,5-0,7] |
15 min | 7,39 [7,36-7,42] | 265 [257–265] | 39 [38–40] | −0,2 [−1,5-0,4] | 0,5 [0,4-0,6] | |
30 min | 7,29 [7,19-7,38] | 254 [248–259] | 48 [41–52] | −3,2 [−8,9- -0,4] | 2,4 [1,7-5,1] | |
45 min | 7,03 [6,99-7,09]*# | 212 [192–247] | 67 [58–77]*# | −12,3 [−15,1- -10,8]*# | 9,0 [8,2-9,9]*# | |
MHNHalothane (n = 10) | 0 min | 7,39 [7,35-7,42] | 247 [201–279] | 43 [39–46] | 0,5 [−1,5-1,1] | 0,6 [0,5-0,8] |
15 min | 7,38 [7,33-7,42] | 249 [195–276] | 43 [39-46| | 0,0 [−1,8-0,9] | 0,8 [0,6-1,0] | |
30 min | 7,39 [7,35-7,49] | 238 [200–253] | 42 [38–46] | −0,3 [−2,2-0,8] | 0,9 [0,5-1,1] | |
45 min | 7,39 [7,34-7,40] | 232 [179–259]* | 40 [39–44] | −1,0 [−2,6-0,6] | 0,6 [0,5-1,0] | |
MHSHalothane+SCh (n = 12) | 0 min | 7,47 [7,41-7,51] | 256 [250–281] | 36 [32–37] | 2,4 [0,3-4,6] | 1,1 [0,9-1,4] |
15 min | 7,42 [7,33-7,44]* | 261 [247–271] | 39 [38–44]* | 0,1 [−2,6-2,1] | 3,1 [1,6-3,6] | |
30 min | 6,90 [6,83-7,13]*# | 256 [194–314]# | 69 [33–87]*# | −18,6 [−23,3- -15,0]*# | 15,7 [15,3-21,4]*# | |
45 min | 6,69+ | 247+ | 42+ | −34,1+ | 29,5+ | |
MHNHalothane+SCh (n = 10) | 0 min | 7,41 [7,41-7,48] | 262 [242–291] | 36 [35–38] | 1,0 [−1,9-3,3] | 1,1 [0,9-1,4] |
15 min | 7,44 [7,37-7,46] | 243 [231–274] | 37 [36–41] | 0,3 [−21-2,8] | 1,1 [0,9-1,4] | |
30 min | 7,38 [7,35-7,44] | 238 [216–274] | 37 [36–38] | −0,4 [−3,6-1,5] | 1,3 [1,0-1,4] | |
45 min | 7,37 [7,34-7,43] | 239 [205–253]* | 39 [37–40] | −2,3 [−4,7- -0,5] | 1,2 [1,1-1,3] |