Table 1 Hemodynamic variables of malignant hyperthermia susceptible (MHS) and non-susceptible (MHN) pigs following succinylcholine or halothane or succinylcholine and halothane application
From: The effect of succinylcholine on malignant hyperthermia events in susceptible swine
Diagnose | Time [min| | HR [bpm] | MAP [mmHg] | SaO2[%] | etCO2[mmHg] | Temperature [°C] |
|---|---|---|---|---|---|---|
MHSSCh (n = 9) | 0 min | 53 [52–61] | 84 [83–89] | 98 [98–98] | 35 [31–35] | 37,3 [37,1-37,3] |
15 min | 58 [53–65] | 85 [82–89] | 98 [97–98] | 35 [32–36] | 37,2 [37,0-37,3] | |
30 min | 73 [63–85]* | 67 [55–74]* | 98 [97–98] | 48 [42–51]*# | 37,5 [37,2-37,5] | |
45 min | 70 [68–92]* | 66 [60–76]* | 98 [97–98] | 54 [44–62]*# | 37,6 [37,3-37,9] | |
MHNSCh (n = 10) | 0 min | 67 [63–72] | 75 [70–86] | 99 [97–100] | 33 [30–35] | 37,0 [36,8-37,5] |
15 min | 71 [63–75] | 74 [67–81] | 99 [96–100] | 33 [30–35] | 36,9 [36,7-37,4] | |
30 min | 72 [67–75] | 72 [68–76] | 99 [98–100] | 34 [31–34] | 37,0 [36,6-37,4] | |
45 min | 66 [61–70] | 71 [69–76] | 99 [97–100] | 34 [31–35] | 37,0 [36,6-37,4] | |
MHSHalothane (n = 6) | 0 min | 61 [60–66] | 82 [75–84] | 98 [98–99] | 33 [30–35] | 37,4 [36,9-37,5] |
15 min | 58 [55–66] | 82 [76–87] | 98 [97–99] | 33 [30–34] | 37,4 [36,9-37,4] | |
30 min | 61 [59–64] | 49 [45–53]*# | 98 [97–99] | 36 [32–40]* | 37,3 [37,0-37,5] | |
45 min | 76 [61–110] | 41 [38–45]* | 97 [95–98] | 55 [44–65]* | 37,5 [37,1-37,9] | |
MHNHalothane (n = 10) | 0 min | 64 [57–70] | 72 [70–79] | 98 [98–100] | 33 [31–35] | 36,8 [36,6-37,3] |
15 min | 64 [55–69] | 73 [68–80] | 98 [97–99] | 35 [31–35] | 37,0 [36,8-37,2] | |
30 min | 68 [61–76] | 66 [55–72]* | 99 [98–100] | 33 [31–34] | 37,1 [36,6-37,2] | |
45 min | 69 [62–73] | 51 [45–56]* | 99 [97–100] | 31 [29–33]*# | 37,0 [36,8-37,3] | |
MHSHalothane+SCh (n = 12) | 0 min | 65 [55–87] | 60 [59–72] | 98 [98–99] | 31 [30–32] | 37,5 [37,4-37,9] |
15 min | 80 [70–92]* | 60 [55–75] | 98 [97–99] | 33 [32–34]* | 37,5 [37,3-37,8] | |
30 min | 168 [113–204]*# | 41 [35–45]* | 96 [95–98]* | 63 [55–65]*# | 38,0 [37,6-38,2]*# | |
45 min | 200+ | 60+ | 98+ | 79+ | 39,5+ | |
MHNHalothane+SCh (n = 10) | 0 min | 71 [61–79] | 67 [60–80] | 99 [97–99] | 33 [31–33] | 37,6 [37,1-37,8] |
15 min | 83 [73–97]* | 61 [60–78] | 98 [97–99] | 32 [31–34] | 37,2 [37,1-37,6]* | |
30 min | 93 [84–102]* | 57 [53–60]* | 98 [96–98] | 31 [30–32] | 37,0 [36,8-37,5]* | |
45 min | 100 [95–105]* | 52 [48–60]* | 96 [95–100] | 32 [30–32] | 36,9 [36,7-37,4]* |