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Table 1 Patient baseline and intraoperative characteristics (n = 40)

From: Tissue oxygenation as a target for goal-directed therapy in high-risk surgery: a pilot study

Characteristics

Control (n = 20)

Intervention (n = 20)

P-value*

Dobu+(n = 10)

P-value§

Age (yr)

75 [69–78]

71 [69–78]

 

71 [69–81]

 

Gender (M/F)

16/4

16/4

 

9/1

 

Body Mass Index (m/kg2)

27 [22–31]

25 [23-27]

 

25 [23–28]

 

Smoking status (%)

60

35

 

40

 

Medical history (n)

     

 COPD

4

4

 

1

 

 CAD

5

9

 

5

 

 CHF

5

3

 

2

 

 IDDM

3

6

 

3

 

 TIA

2

2

 

1

 

Hemoglobine (g/dl)

12.2 [10.6-14.5]

13.7 [12.6-15.3]

0.34

13.4 [10.6-15.6]

0.25

Type of surgery (n)

  

0.18

 

0.13

 AAA

9

5

 

2

 

 Oesophagus

1

2

 

2

 

 Stomach

1

3

 

1

 

 Pancreas

1

5

 

4

 

 Colon

3

2

 

0

 

 Other

5

3

 

1

 

Duration surgery (min)

277 [221–334]

262 [145–387]

0.63

349 [246–500]

0.35

Blood loss (ml)

800 [350–1575]

375 [200–950]

0.07

550 [288–1050]

0.22

RBC transfusion (ml)

0 [0–300]

0 [0–0]

0.06

0 [0–150]

0.32

Colloids (ml)

1000 [563–1000]

500 [0–1500]

0.40

1000 [500–1625]

0.83

Crystalloids (ml)

3000 [2350–3875]

2725 [2075–3500]

0.80

3400 [2500–4125]

0.57

Norepinephrine (%)

50

75

 

90

 

Hemoglobine (g/dl)

10.8 [9.2-12.6]

10.9 [9.9-12.3]

0.73

11.4 [9.3-12.4]

0.74

 StO2 - baseline (%)

86 [83–90]

86 [81–90]

0.68

81 [78–84]

0.01

 StO2 - average (%)

83 [77–87]

85 [78–91]

0.45

78 [74–82]

0.07

 StO2 - minimum (%)

71 [59–79]

76 [70–82]

0.22

70 [57–72]

0.40

 ScvO2 - baseline (%)

80 [70–85]

81 [75–84]

0.91

75 [74–83]

0.53

 ScvO2 - average (%)

77 [70–81]

81 [77–83]

0.09

78 [72–83]

0.35

 ScvO2 - minimum (%)

61 [55–68]

70 [59–72]

0.13

65 [57–72]

0.38

  1. Dobu +, subgroup of intervention subjects that did receive dobutamine; COPD, chronic obstructive pulmonary disease; CAD, coronary artery disease; CHF, chronic heart failure; IDDM, insulin dependent diabetes mellitus; TIA, transient ischemic attack; AAA, abdominal aortic aneurysm; RBC, red blood cell; StO2, tissue oxygenation; ScvO2, central venous oxygen saturation; baseline: start surgery; *Control versus Intervention; § Control versus Dobu+.