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Table 5 Patients’ characteristics according to the achievement of an optimal fibrinogen level ≥2 g/L (maximum fibrinogen level within 24 hours after the onset of bleeding)

From: Administration of fibrinogen concentrate for refractory bleeding in massively transfused, non-trauma patients with coagulopathy: a retrospective study with comparator group

Variables

Fibrinogen ≥ 2 g/l N = 77

Fibrinogen < 2 g/l N = 64

P value

Age (years)

61 [48, 70]

59 [44, 67]

NS

SOFA

5 [3, 8]

6 [4, 9]

NS

Gender (males)

54 (54.5)

45 (45.5)

NS

FBN administration

0 [0, 2]

2 [0, 3]

0.00

Haemorrhage occurring outside the OR or ICU

22 (28.5)

26 (40.6)

NS

Diagnoses

   

Cardiac surgery

43 (55.8)

28 (43.8)

 

Liver transplantation

12 (15.6)

10 (15.6)

 

Gastrointestinal bleeding

13 (16.9)

18 (28.1)

NS

Other

9 (11.7)

8 (12,7)

 

Variables at beginning of the bleeding

   

pH

7.3 [7.3, 7.4]

7.3 [7.2, 7.3]

0.04

Base excess (mEq/L)

-3 [-7, -2]

-6 [-9, -4]

NS

Creatinine (mg/dl)

0.9 [0.7, 1.6]

0.9 [0.7, 1.3]

NS

Leukocytes (x 109/L)

9.9 [7.0, 14.5]

7.9 [4.7, 12.9]

0.02

Platelets (x 109/L)

109 [65, 164]

88 [50, 126]

0.04

Haemoglobin (g/L)

74.0 [66.7, 85.0]

76.0 [65.0, 87.0]

NS

Prothrombin time (s)

16 [14, 21]

19 [16, 27]

0.02

Thromboplastin Time (s)

38 [31, 55]

58 [33, 74]

0.03

Fibrinogen (g/L)

2.1 [1.5, 3.2]

1.3 [1.0, 1.7]

0.00

INR

1.4 [1.2, 1.8]

1.7 [1.3, 2.4]

0.01

Outcome variables

   

Length hospital stay (days)

18 [10, 32]

18 [8, 26]

NS

PRBC (units)

7 [5, 9]

12 [6, 18]

0.00

FFP (units)

3 [0, 5]

4 [0, 8]

NS

Platelet (pools)

1 [0, 2]

2 [1, 4]

0.00

Total transfusion (units)

10 [6, 16]

16 [7, 30]

0.00

Mortality

22 (28.6)

27 (42.2)

NS