Variables | Fibrinogen ≥ 2 g/l N = 77 | Fibrinogen < 2 g/l N = 64 | P value |
---|---|---|---|
Age (years) | 61 [48, 70] | 59 [44, 67] | NS |
SOFA | 5 [3, 8] | 6 [4, 9] | NS |
Gender (males) | 54 (54.5) | 45 (45.5) | NS |
FBN administration | 0 [0, 2] | 2 [0, 3] | 0.00 |
Haemorrhage occurring outside the OR or ICU | 22 (28.5) | 26 (40.6) | NS |
Diagnoses | |||
Cardiac surgery | 43 (55.8) | 28 (43.8) | |
Liver transplantation | 12 (15.6) | 10 (15.6) | |
Gastrointestinal bleeding | 13 (16.9) | 18 (28.1) | NS |
Other | 9 (11.7) | 8 (12,7) | |
Variables at beginning of the bleeding | |||
pH | 7.3 [7.3, 7.4] | 7.3 [7.2, 7.3] | 0.04 |
Base excess (mEq/L) | -3 [-7, -2] | -6 [-9, -4] | NS |
Creatinine (mg/dl) | 0.9 [0.7, 1.6] | 0.9 [0.7, 1.3] | NS |
Leukocytes (x 109/L) | 9.9 [7.0, 14.5] | 7.9 [4.7, 12.9] | 0.02 |
Platelets (x 109/L) | 109 [65, 164] | 88 [50, 126] | 0.04 |
Haemoglobin (g/L) | 74.0 [66.7, 85.0] | 76.0 [65.0, 87.0] | NS |
Prothrombin time (s) | 16 [14, 21] | 19 [16, 27] | 0.02 |
Thromboplastin Time (s) | 38 [31, 55] | 58 [33, 74] | 0.03 |
Fibrinogen (g/L) | 2.1 [1.5, 3.2] | 1.3 [1.0, 1.7] | 0.00 |
INR | 1.4 [1.2, 1.8] | 1.7 [1.3, 2.4] | 0.01 |
Outcome variables | |||
Length hospital stay (days) | 18 [10, 32] | 18 [8, 26] | NS |
PRBC (units) | 7 [5, 9] | 12 [6, 18] | 0.00 |
FFP (units) | 3 [0, 5] | 4 [0, 8] | NS |
Platelet (pools) | 1 [0, 2] | 2 [1, 4] | 0.00 |
Total transfusion (units) | 10 [6, 16] | 16 [7, 30] | 0.00 |
Mortality | 22 (28.6) | 27 (42.2) | NS |