Administration of fibrinogen concentrate for refractory bleeding in massively transfused, non-trauma patients with coagulopathy: a retrospective study with comparator group

Table 2 Laboratory values and transfused units before and after FBNc administration

Variables	Pre-FBNc	Post-FBNc	P value
pH	7.30 [7.28, 7.32]	7.32 [7.26, 7.36]	0.03
Base excess (mEq/L)	-4.3 [-8.0, -3.0]	-4.0 [-7.0, -2.0]	NS
Creatinine (mg/dl)	0.9 [0.7, 1.2]	0.9 [0.7, 1.3]	NS
Platelets (x 10⁹/L)	93 [48, 156]	80 [59, 114]	NS
Haemoglobin (g/L)	85.0 [71.0, 106.0]	90.0 [76.0, 100.0]	NS
Prothrombin time (s)	19.2 [14.0, 31.9]	18.0 [15.4, 24.1]	NS
Thromboplastin time (s)	46.1 [33.7, 98.6]	41.3 [32.6, 58.2]	0.02
Fibrinogen (g/L)	1.3 [0.9, 2.3]	1.8 [1.2, 2.3]	NS
INR	1.7 [1.2, 2.8]	1.6 [1.3, 2.0]	NS
*Outcome variables*
PRBC (units)	4 [3, 6]	2 [1, 3]	0.00
FFP (units)	1 [0, 2]	0 [0, 2]	NS
Platelet (pools)	1 [0, 2]	0 [0, 1]	0.00
Total (units)	6 [5, 9]	3 [1, 6]	0.00
Bleeding (mL)*	1000 [670, 2000]	450 [242, 700]	0.00

Only patients receiving FBNc (N = 71) are considered (within-group comparison). *Bleeding was measured accurately only in 33 patients. (See caption for Table 1 for details).

ISSN: 1471-2253