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Table 1 Baseline data in the study cohort

From: The influence of statin exposure on inflammatory markers in patients with early bacterial infection: pilot prospective cohort study

Variable

Combined (n = 209)

Statin (n = 58)

Non-statin (n = 151)

p-value1

Age (yr), mean ± SD

63.8 ± 20.7

75.4 ± 11.3

59.4 ± 21.8

<0.0001

Gender (male), n (%)

104 (49.8)

27 (46.6)

77 (51)

0.57

Charlson Index, median (IQR)

2 (1–3)

3 (2–4)

1 (0–3)

<0.0001

Type of infection 2

Pneumonia

106 (51.0)

27 (46.6)

79 (52.7)

0.43

Primary bacteraemia

6 (2.9)

2 (3.5)

4 (2.7)

0.68

Peritonitis/intra-abdominal

7 (3.4)

2 (3.5)

5 (3.4)

1.00

Urinary tract

70 (34.1)

23 (39.7)

47 (32.0)

0.30

Skin/soft tissue

38 (18.5)

12 (20.7)

26 (17.7)

0.69

Other 3

5 (2.7)

0 (0)

5 (3.3)

0.3252

CRP (mg/L) (n = 176; 47; 129), median (IQR)

65 (17–166)

87 (32–157)

58 (16–166)

0.51

WCC ( ×10 9 /L) (n = 186; 48; 138), median (IQR)

13.1 (9.1–17.7)

13.2 (9.4–17.9)

12.9 (9.0–17.6)

0.64

Lowest systolic BP (mmHg) (n = 200; 54; 146), mean ± SD

115 ± 22.1

119.4 ± 26.0

113.9 ± 20.3

0.12

Highest temperature (Celsius) (n = 201; 55; 146), mean ± SD

37.4 ± 0.99

37.4 ± 1.04

37.4 ± 0.97

0.70

Lowest temperature (Celsius) (n = 199; 54; 145), mean ± SD

36.5 ± 0.75

36.6 ± 0.80

36.4 ± 0.73

0.26

At least 1 SIRS criterion, n (%)

184 (88.0)

50 (86.2)

134 (88.7)

0.61

Lowest SaO 2 < 90%, n (%)

22 (11.1)

8 (14.8)

14 (9.7)

0.30

Supplemental oxygen (n, %)

105 (50.5)

30 (51.7)

75 (50.0)

0.82

Urine output (median [IQR]), (n = 40; 12; 28)

750 (450–1237.5)

877.5 (417–1875)

750 (450–1237.5)

0.74

AVPU (n, %) (n = 191; 54; 137)

   

0.069

Alert

186 (97.4)

51 (94.4)

135 (98.5)

 

Responds to Voice

4 (2.1)

3 (5.6)

1 (0.73)

 

Responds to Pain

0 (0)

0 (0)

0 (0)

 

Unresponsive

1 (0.5)

0 (0)

1 (0.73)

 
  1. Data refer to the first day of admission. Numbers in brackets, where provided, refer to the number of patients with data.
  2. 1For difference between statin versus non-statin groups.
  3. 2211 infections were identified. 4 patients did not have infection and 7 patients had >1 infection.
  4. 3Other infections included C. difficile (n = 1), osteomyelitis (n = 2), tonsillitis (n = 1), gastroenteritis (n = 1).