Table 2 Cohort distribution of mortality by demographic and clinical variables and by severity criteria
Variable | Category | N in category+ | 30 day mortality | OR (95% CI) for death within 30 days | 90 day mortality | OR (95% CI) for death within 90 days |
|---|---|---|---|---|---|---|
Age group | <60 yrs | 171 | 8% | 1.00 | 13% | 1.00 |
60–69 yrs | 127 | 9% | 1.06 (0.47–2.43) | 10% | 0.73 (0.36–1.51) | |
70–79 yrs | 174 | 20% | 2.82 (1.46–5.47)** | 31% | 2.90 (1.68–4.99)** | |
≥80 yrs | 168 | 38% | 6.90 (3.68–12.95)** | 53% | 7.43 (4.35–12.66)** | |
Gender | Male | 351 | 18% | 1.00 | 27% | 1.00 |
Female | 289 | 21% | 1.22 (0.83–1.81) | 30% | 1.16 (0.82–1.64) | |
SIMD quintile | 1 Deprived | 130 | 19% | 1.00 | 26% | 1.00 |
2 | 107 | 21% | 1.09 (0.57–2.06) | 30% | 1.21 (0.68–2.13) | |
3 | 115 | 24% | 1.35 (0.74–2.49) | 36% | 1.56 (0.91–2.70) | |
4 | 161 | 18% | 0.92 (0.51–1.67) | 28% | 1.10 (0.65–1.84) | |
5 Affluent | 111 | 18% | 0.92 (0.48–1.77) | 24% | 0.91 (0.51–1.63) | |
Charlson index | 0 | 133 | 12% | 1.00 | 16% | 1.00 |
1 | 170 | 15% | 1.33 (0.68–2.60) | 24% | 1.71 (0.95–3.06) | |
2 | 137 | 22% | 2.03 (1.05–3.93)* | 32% | 2.50 (1.39–4.49)** | |
≥3 | 200 | 26% | 2.57 (1.40–4.73)** | 37% | 3.13 (1.81–5.42)** | |
Admission type | Elective | 129 | 3% | 1.00 | 5% | 1.00 |
Emergency | 511 | 23% | 9.59 (3.47–26.50)** | 34% | 10.59 (4.57–24.51)** | |
Ward type | Medicine | 281 | 30% | 1.00 | 40% | 1.00 |
Surgery | 244 | 11% | 0.28 (0.17–0.45)** | 16% | 0.30 (0.20–0.45)** | |
Orthopaedics | 68 | 10% | 0.27 (0.12–0.61)** | 21% | 0.39 (0.21–0.74)** | |
Other | 47 | 15% | 0.41 (0.18–0.95)* | 29% | 0.64 (0.33–1.25) | |
Length of stay prior to sepsis onset | 1–3 days | 187 | 11% | 1.00 | 17% | 1.00 |
4–7 days | 139 | 18% | 1.83 (0.97–3.45) | 27% | 1.83 (1.07–3.13)* | |
8–21 days | 213 | 23% | 2.50 (1.42–4.38)** | 33% | 2.52 (1.56–4.06)** | |
>21 days | 101 | 29% | 3.53 (1.88–6.63)** | 40% | 3.44 (1.98–5.98)** | |
Blood culture result | Negative | 418 | 18% | 1.00 | 26% | 1.00 |
Contaminant | 65 | 22% | 1.22 (0.64–2.31) | 32% | 1.39 (0.79–2.44) | |
Positive | 150 | 21% | 1.20 (0.76–1.91) | 34% | 1.50 (1.00–2.24)* | |
SIRS criteria | 2 | 227 | 13% | 1.00 | 22% | 1.00 |
3 | 279 | 19% | 1.60 (0.98–2.62) | 29% | 1.51 (1.01–2.27)* | |
4 | 132 | 31% | 3.08 (1.80–5.26)* | 36% | 2.08 (1.29–3.34)** | |
SEWS score | 0–1 | 95 | 15% | 1.00 | 26% | 1.00 |
2–3 | 242 | 15% | 1.01 (0.52–1.97) | 19% | 0.66 (0.38–1.15) | |
4–5 | 182 | 21% | 1.53 (0.78–2.99) | 35% | 1.48 (0.86–2.57) | |
≥6 | 121 | 30% | 2.45 (1.23–4.88)** | 38% | 1.72 (0.96–3.09) | |
CURB65 score | 0 | 112 | 3% | 1.00 | 6% | 1.00 |
1 | 179 | 11% | 4.57 (1.33–15.76)* | 17% | 3.14 (1.33–7.41)** | |
2 | 190 | 23% | 10.95 (3.31–36.19)** | 34% | 7.80 (3.43–17.74)** | |
≥3 | 159 | 36% | 20.30 (6.17–66.87)** | 48% | 14.09 (6.17–32.17)** | |
IHI criteria | Not severe | 431 | 14% | 1.00 | 23% | 1.00 |
Severe | 207 | 29% | 2.49 (1.66–3.72)** | 39% | 2.11 (1.48–3.02)** | |
SSC criteria | Not severe | 468 | 14% | 1.00 | 22% | 1.00 |
Severe | 172 | 34% | 3.24 (2.15–4.88)** | 45% | 2.87 (1.98–4.17)** | |
Survive Sepsis criteria | Not severe | 450 | 15% | 1.00 | 23% | 1.00 |
Severe | 188 | 30% | 2.53 (1.69–3.80)** | 39% | 2.13 (1.48–3.07)** |