The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation

Table 1 Study drugs for which mechanistic and clinical pharmacokinetic (PK) data will be generated

Studies	Sedatives & analgesics	Antivirals /antifungals	Antibacterials
Ex vivo stability	Morphine	Fluconazole	Ceftriaxone
Ex vivo circuits	Morphine -3 -glucuronide	Caspofungin	Meropenem
Ovine ECMO	Morphine -6 –glucuronide		Vancomycin
Population PK	Fentanyl, nor-fentanyl		Ciprofloxacin
	Midazolam		Gentamicin*
	1 & 4 hydroxy midazolam		Gentamicin*
Ex vivo stability	Propofol ,Thiopentone	Oseltamivir	Piperacillin/tazobactum Ticarcillin/clavulunate
Population PK	Dexmedetomidine	Voriconazole	Cefepime, Linezolid

OC –oseltamivir carboxylate. * Gentamicin will not included in the ex vivo circuit studies due to its incompatibility with other study drugs.

ISSN: 1471-2253