Figure 4
Effects of xylazine on the glucose metabolic rate in fasted normoglycemic rhesus monkeys. Hyperinsulinemia was maintained by insulin infusion at a constant rate of 40 mU/m2 Surface Area*min. Glucose was infused simultaneously to adjust and balance blood glucose for a period of 95 ± 11 min and then to achieve euglycemia (55 – 75 mg/dL) stably for 40 min with a constant infusion rate. Xylazine (2 mg/kg) was then injected intramuscularly. To hold blood glucose concentration constantly in the pre-xylazine range (55 – 75 mg/dL), the glucose infusion rate was decreased during next 40 min after xylazine administration. The glucose infusion rates were calculated as the glucose metabolic rates (M rates) at the times before (Pre-xylazine) and after (Xylazine) xylazine administration. **, p < 0.01; vs. Pre-xylazine.