Table 2 Hemodynamic and general management data
From: The aPC treatment improves microcirculation in severe sepsis/septic shock syndrome
| Â | Â | Bsln | T1a (+24Â h) | T1b (+48Â h) | T1c (+72Â h) | T2 (6Â h after aPC stop) |
|---|---|---|---|---|---|---|
MAP (mmHg) | aPC | 78 (71–86) | 88 (73–95) | 91 (79–94) | 89 (78–98) | 97 (81–102) # |
|  | no-aPC | 74 (65–85) | 76 (67–87) | 80 (79–88) | 82 (72–87) | 78 (70–86) |
CI (L/min/m2) | aPC | 4.4 (3.5–5.3) | 4.2 (3.5–5.4) | 4.2 (3.9–4.3) | 3.9 (3.4–4.7) | 4.1 (3.5–4.4) |
|  | no-aPC | 4.2 (3.4–4.3) | 3.9 (3–4.7) | 3.9 (3.7–4.5) | 4 (3.4–4.3) | 4 (3.5–4.2) |
ITBVI (mL/m2) | aPC | 908 (750–1129) | 878 (744–993) | 863 (762–1083) | 922 (799–1003) | 855 (789–966) |
|  | no-aPC | 1003 (945–1135) | 997 (910–1071) | 970 (860–1095) | 918 (853–1050) | 905 (847–992) |
PaO2/FiO2 | aPC | 188 (135–291) | 195 (161–296) | 220 (158–286) | 220 (193–253) | 248 (219–301) ## |
|  | no-aPC | 190 (189–287) | 180 (173–251) | 201 (184–238) | 201 (156–266) | 209 (162–325) |
BE (mEq/L) | aPC | −1.9 (−7.5–1.2) | 1.4 (−3.5–5.5) | 3.5 (−0.3–7.2) # | 5.8 (−1.4–8.2) ## | 6.3 (−0.9–8.8) # |
|  | no-aPC | 2.8 (−4.8–4.9) | 4.3 (0.6–6) | 5.3 (−1.1–8.3) | 1.7 (−2.1–8.5) | 1.6 (−2.8–8.6) |
Lac (mmol/L) | aPC | 2.7 (1.5–3) | 1.7 (1.4–2.8) | 1.5 (1.4–2.4) | 2 (1.3–2.4) | 1.5 (1.1–1.9) # ††|
|  | no-aPC | 2.8 (1.6–3.8) | 2.3 (1.3–4.2) | 1.6 (1.2–2.9) | 1.2 (1–2.5) | 1.5 (1.2–2.8) |
Nora (μg/kg/min) | aPC | 0.29 (0.17–0.48) | 0.27 (0.16–0.48) | 0.22 (0.04–0.46) | 0.21 (0–0.46) | 0.03 (0–0.46) # |
|  | no-aPC | 0.41 (0.16–0.51) | 0.41 (0.19–0.63) | 0.28 (0.1–0.66) | 0.25 (0.11–0.56) | 0.15 (0.11–0.52) |
SOFA score | aPC | 11 (10–14) | 11 (8–13) | 10 (8–11) | 9 (7–11) ## | 8 (6–9) ### †††** |
|  | no-aPC | 10 (8–14) | 12 (7–15) | 11 (7–17) | 11 (7–16) | 11 (9–17) § |