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Table 2 Hemodynamic and general management data

From: The aPC treatment improves microcirculation in severe sepsis/septic shock syndrome

   Bsln T1a (+24 h) T1b (+48 h) T1c (+72 h) T2 (6 h after aPC stop)
MAP (mmHg) aPC 78 (71–86) 88 (73–95) 91 (79–94) 89 (78–98) 97 (81–102) #
  no-aPC 74 (65–85) 76 (67–87) 80 (79–88) 82 (72–87) 78 (70–86)
CI (L/min/m2) aPC 4.4 (3.5–5.3) 4.2 (3.5–5.4) 4.2 (3.9–4.3) 3.9 (3.4–4.7) 4.1 (3.5–4.4)
  no-aPC 4.2 (3.4–4.3) 3.9 (3–4.7) 3.9 (3.7–4.5) 4 (3.4–4.3) 4 (3.5–4.2)
ITBVI (mL/m2) aPC 908 (750–1129) 878 (744–993) 863 (762–1083) 922 (799–1003) 855 (789–966)
  no-aPC 1003 (945–1135) 997 (910–1071) 970 (860–1095) 918 (853–1050) 905 (847–992)
PaO2/FiO2 aPC 188 (135–291) 195 (161–296) 220 (158–286) 220 (193–253) 248 (219–301) ##
  no-aPC 190 (189–287) 180 (173–251) 201 (184–238) 201 (156–266) 209 (162–325)
BE (mEq/L) aPC −1.9 (−7.5–1.2) 1.4 (−3.5–5.5) 3.5 (−0.3–7.2) # 5.8 (−1.4–8.2) ## 6.3 (−0.9–8.8) #
  no-aPC 2.8 (−4.8–4.9) 4.3 (0.6–6) 5.3 (−1.1–8.3) 1.7 (−2.1–8.5) 1.6 (−2.8–8.6)
Lac (mmol/L) aPC 2.7 (1.5–3) 1.7 (1.4–2.8) 1.5 (1.4–2.4) 2 (1.3–2.4) 1.5 (1.1–1.9) # ††
  no-aPC 2.8 (1.6–3.8) 2.3 (1.3–4.2) 1.6 (1.2–2.9) 1.2 (1–2.5) 1.5 (1.2–2.8)
Nora (μg/kg/min) aPC 0.29 (0.17–0.48) 0.27 (0.16–0.48) 0.22 (0.04–0.46) 0.21 (0–0.46) 0.03 (0–0.46) #
  no-aPC 0.41 (0.16–0.51) 0.41 (0.19–0.63) 0.28 (0.1–0.66) 0.25 (0.11–0.56) 0.15 (0.11–0.52)
SOFA score aPC 11 (10–14) 11 (8–13) 10 (8–11) 9 (7–11) ## 8 (6–9) ### ††† **
  no-aPC 10 (8–14) 12 (7–15) 11 (7–17) 11 (7–16) 11 (9–17) §
  1. *p < 0.05, aPC group vs. no-aPC group at the same time point (** p < 0.01).
  2. #p < 0.05, vs. T0 in the aPC-group (## p < 0.01; ### p < 0.0001).
  3. §p < 0.05, vs. T0 in the no-aPC group.
  4. †††p < 0.0001, vs. T1a in the aPC-group.