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Table 2 Applied trigger agents and clinical presentations of malignant hyperthermia suspected events

From: Evaluation of suspected malignant hyperthermia events during anesthesia

No IVCT Trigger agents Masseterspasm Dantrolene application Cardiac arrhythmia Max. end-tidal CO2[mmHg] Max. temperature Max. Creatine kinase [U/L]
1 MHS Isoflurane + SCh Unknown 1 × 200 mg Sinus tachycardia 48 mmHg 38.8°C 10.514
2 MHS Isoflurane + SCh Yes 1 × 240 mg Tachyarrhythmia 54 mmHg 36.1°C > 10.000
3 MHS Sevoflurane + SCh Yes No Sinus tachycardia Unknown Unknown 51.557
4 MHS Sevoflurane + SCh Unknown 2 × 200 mg Sinus tachycardia 62 mmHg Unknown 23.700
5 MHS Desflurane + SCh Unknown 1 × 220 mg Tachyarrhythmia 56 mmHg 37.6°C ≈ 80.000
6 MHS Sevoflurane No 1 × 200 mg No 85 mmHg 37.5°C 38.762
7 MHS Isoflurane + SCh Unknown No Unknown Unknown Unknown 16.412
8 MHEh SCh Yes 1 × 200 mg Unknown 39 mmHg Unknown 119.150
9 MHEh SCh Yes Unknown No 36 mmHg Unknown 162
10 MHEh SCh Yes No Unknown Unknown Unknown 2.234
11 MHEh Halothane + SCh Yes Unknown Tachyarrhythmia Unknown Unknown Low
12 MHN SCh Yes No Tachyarrhythmia Unknown Unknown 132
13 MHN Isoflurane Yes No Unknown 54 mmHg Unknown 4.100
14 MHN SCh Yes No Unknown Unknown Unknown 24.732
15 MHN Desflurane No 1 × 180 mg Tachyarrhythmia 72 mmHg Unknown Unknown
16 MHN SCh Yes No Unknown Unknown Unknown Unknown
17 MHN Desflurane No No Unknown Unknown 38,5°C Unknown
18 MHN Isoflurane + SCh Yes No Unknown 41 mmHg Unknown 5.174
19 MHN Enflurane + SCh Yes No Unknown 75 mmHg Unknown 4.820
  1. IVCT In vitro contracture test, MHS Malignant hyperthermia susceptible, MHN malignant hyperthermia non-susceptible, MHEh Malignant hyperthermia equivocal to halothane, SCh Succinylcholine, CO 2 Carbon dioxide.