A latent class approach for sepsis diagnosis supports use of procalcitonin in the emergency room for diagnosis of severe sepsis

Table 4 Diagnostic accuracy of CRP, DD and PCT for sepsis diagnosis according to the LCA gold standard

Operating characteristics	CRP	DD	PCT
Operating characteristics	(12 mg/dl)	(1848 ng/ml)	(2.06 ng/ml)
AUC - ROC	0.71	0.73	0.95
AUC - ROC	(0.68 – 0.74)	(0.69 – 0.76)	(0.93 – 0.96)
Sensitivity	64.17%	65.24%	91.44%
Sensitivity	(0.57 – 0.71)	(0.58 – 0.72)	(0.86 – 0.95)
Specificity	64.47%	65.23%	91.35%
Specificity	(0.60 – 0.68)	(0.61 – 0.69)	(0.89 – 0.94)
LR +	1.81	1.88	10.81
LR +	(1.54 – 2.11)	(1.60 – 2.19)	(8.15 – 14.35)
LR -	0.56	0.53	0.09
LR -	(0.45 – 0.68)	(0.43 – 0.66)	(0.06 – 0.15)

Values between parentheses are cut-off points and 95% Confidence Interval, respectively. LR, likelihood ratio.

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