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Table 3 Clinical characteristics at admission according to the LCA classification in clusters

From: A latent class approach for sepsis diagnosis supports use of procalcitonin in the emergency room for diagnosis of severe sepsis

Clinical

Cluster 2

Cluster 1

Missing

P* value

characteristics

n = 532

n = 187

n = 46

Age

51 (33–68, 532)

54 (37–70, 187)

39 (23–62, 46)

0.067

SOFA score

2 (1–3, 532)

4 (3–6, 187)

2 (1–3, 46)

0.001

APACHE II score

8 (5–13, 532)

13 (9–17,187)

8 (3–11, 46)

0.001

Temperature (°C)

37 (36.5-37.2, 489)

37 (36.7-38, 173)

37 (36.5-38, 43)

0.061

Heart rate

92 (80–108, 520)

100 (88–117, 182)

96 (81–114, 43)

0.001

Respiratory rate

20 (18–28, 90)

24 (20–29, 61)

26.5 (20–38.5, 12)

0.048

MAP

79 (68–90, 495)

72.5 (61–83, 180)

70.5 (60–77, 42)

0.001

WBC (cells/mm3)

11200 (8200–15100, 527)

13250 (9300–19300, 186)

13100 (9300–16700, 46)

0.005

Creatinin (mg/dl)

0.9 (0.8-1.3, 529)

1.4 (0.9-2.6, 185)

0.9 (0.7-1.6, 42)

0.001

Platelets (cells/mm3)

296000

237000

297000

0.001

(223000–391000, 525)

(147000–301000, 183)

(186000–404000, 46)

PaFi

324 (240–384, 515)

292 (190–355, 182)

332 (220–392, 41)

0.001

Lactic Acid (mmo/L)

1.6 (1.1-2.5, 518)

2.0 (1.3-3.1, 184)

1.8 (1.6-2.8, 41)

0.001

Suspected source of infection

   

0.001

Respiratory

129 (24%)

41 (22%)

9 (19%)

 

Urinary tract

76 (14%)

44 (23%)

7 (15%)

 

Skin and soft tissues

147 (28%)

20 (11%)

9 (19%)

 

Intra-abdominal

60 (11%)

27 (14%)

6 (13%)

 

Undetermined

47 (9%)

37 (20%)

10 (22%)

 

Others

73 (14%)

18 (10%)

5 (11%)

 

No comorbidity

237 (44%)

73 (39%)

28 (61%)

0.027

Diabetes

108 (20%)

33 (18%)

5 (11%)

0.250

COPD

69 (13%)

21 (11%)

4 (9%)

0.614

CRF

54 (10%)

32 (17%)

2 (4%)

0.011

28-day mortality rate

50 (9)

32 (17)

9 (19)

0.005

Blood culture requested

293 (55)

146 (78)

28 (61)

0.001

Positive blood culture

34 (12)

57 (39)

7 (25)

0.001

Procalcitonin (ng/ml)

0.21 (0.05 – 0.64)

15.07 (6.78 – 31.96)

0.64 (0.08 – 3.63)

0.0001

C reactive protein (mg/dl)

7 (2.3 – 15.65)

18.8 (8.3 – 25.9)

13.3 (8.3 – 21.7)

0.0001

D- dimer (ng/ml)

1406 (893 – 2329)

2883 (1386 – 5018)

1700 (1279 – 2398)

0.0001

  1. The values are expressed as median (IQR, observations available) or number (percentage).
  2. Missing = patients without information in any of PCT, CRP or DD; Cluster 1 = patients identified by LCA as a sepsis-like syndrome; Cluster 2 = the remaining of the study population; MAP, Mean Arterial Pressure; WBC, White Blood Cells; PaFi, PaO2/FiO2; COPD, Chronic obstructive pulmonary disease; CRF, Chronic renal failure.
  3. *Kruskal-Wallis for continuous variables and Chi-square for proportions.
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BMC Anesthesiology

ISSN: 1471-2253

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