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Table 2 Diagnostic accuracy of CRP, DD and PCT for sepsis diagnosis at admission in the ER according to expert consensus

From: A latent class approach for sepsis diagnosis supports use of procalcitonin in the emergency room for diagnosis of severe sepsis

 

Measurement 1

Measurement 2

Operating characteristics

CRP

DD

PCT

CRP

DD

PCT

(7.8 mg/dl)

(1616 ng/ml)

(0.30 ng/ml)

(9.3 mg/dl)

(1485 ng/ml)

(0.27 ng/ml)

AUC – ROC

0.71

0.55

0.69

0.72

0.55

0.70

(0.67 – 0.74)

(0.51 – 0.58)

(0.65 – 0.72)

(0.68 – 0.75)

(0.51 – 0.58)

(0.67 – 0.73)

Sensitivity

66.6%

51.4%

63.8%

68.9%

52.7%

67.2%

(0.62 – 0.71)

(0.47 – 0.56)

(0.59 – 0.68)

(0.64 – 0.73)

(0.48 – 0.57)

(0.63 – 0.71)

Specificity

66.1%

51.6%

63.9%

68.7%

52.7%

66.4%

(0.60 – 0.72)

(0.45 – 0.58)

(0.58 – 0.70)

(0.62 – 0.74)

(0.46 – 0.59)

(0.60 – 0.72)

LR +

1.97

1.06

1.77

2.20

1.12

2.00

(1.64 – 2.36)

(0.91 – 1.24)

(1.48 – 2.11)

(1.81 – 2.68)

(0.95 – 1.31)

(1.65 – 2.41)

LR -

0.50

0.94

0.57

0.45

0.90

0.49

(0.44 – 0.58)

(0.82 – 1.08)

(0.49 – 0.65)

(0.39 – 0.53)

(0.78 – 1.03)

(0.43 – 0.57)

  1. Values between parentheses are cut-off points and 95% Confidence Interval, respectively. LR, Likelihood ratio.