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Table 2 Diagnostic accuracy of CRP, DD and PCT for sepsis diagnosis at admission in the ER according to expert consensus

From: A latent class approach for sepsis diagnosis supports use of procalcitonin in the emergency room for diagnosis of severe sepsis

  Measurement 1 Measurement 2
Operating characteristics CRP DD PCT CRP DD PCT
(7.8 mg/dl) (1616 ng/ml) (0.30 ng/ml) (9.3 mg/dl) (1485 ng/ml) (0.27 ng/ml)
AUC – ROC 0.71 0.55 0.69 0.72 0.55 0.70
(0.67 – 0.74) (0.51 – 0.58) (0.65 – 0.72) (0.68 – 0.75) (0.51 – 0.58) (0.67 – 0.73)
Sensitivity 66.6% 51.4% 63.8% 68.9% 52.7% 67.2%
(0.62 – 0.71) (0.47 – 0.56) (0.59 – 0.68) (0.64 – 0.73) (0.48 – 0.57) (0.63 – 0.71)
Specificity 66.1% 51.6% 63.9% 68.7% 52.7% 66.4%
(0.60 – 0.72) (0.45 – 0.58) (0.58 – 0.70) (0.62 – 0.74) (0.46 – 0.59) (0.60 – 0.72)
LR + 1.97 1.06 1.77 2.20 1.12 2.00
(1.64 – 2.36) (0.91 – 1.24) (1.48 – 2.11) (1.81 – 2.68) (0.95 – 1.31) (1.65 – 2.41)
LR - 0.50 0.94 0.57 0.45 0.90 0.49
(0.44 – 0.58) (0.82 – 1.08) (0.49 – 0.65) (0.39 – 0.53) (0.78 – 1.03) (0.43 – 0.57)
  1. Values between parentheses are cut-off points and 95% Confidence Interval, respectively. LR, Likelihood ratio.