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Table 3 Haemodynamic variables and microcirculatory parameters for T0 and T30

From: Elevated central venous pressure is associated with impairment of microcirculatory blood flow in sepsis: a hypothesis generating post hoc analysis

  T = 0 (n = 70 patients) T = 30 (n = 70 patients) P a
MAP (mmHg) 71 ± 12 68 ± 13 0.008*
Cardiac index (l/min/m 2 ) 4.2 ± 1.3 4.1 ± 1.3 0.291
CVP (mmHg) 12.6 ± 4.8 11.9 ± 4.3 0.017*
Perfusion pressure (mmHg) 59 ± 13 56 ± 13 0.034*
PEEP (cm H 2 O) 13 ± 3 13 ± 3 0.425
SvO 2 (%) 71 ± 7.4 70 ± 8.4 0.141
Lactate (mmol/L) 2.6 ± 2.2 2.6 ± 2.3 0.779
Dopamine (n,%, μg/kg/min) 60, 86, 5.8 ± 3.7 61, 87, 5.9 ± 3.7 0.772
Norepinephrine (n,%, μg/kg/min) 33, 47, 0.07 ± 0.11 35, 50, 0.07 ± 0.15 0.401
MFI (AU) 1.58 ± 1.62 1.81 ± 0.92 0.027*
PPV (%) 91 ± 18 94 ± 12 0.197
TVD (mm/mm 2 ) 14.27 ± 2.22 14.08 ± 2.01 0.415
PVD (mm/mm 2 ) 14.11 ± 10.84 13.28 ± 2.71 0.496
  1. Mean ± SD unless specified otherwise. T0: directly after fulfillment of resuscitation endpoints. T30: 30 minutes after T0. CVP = Central venous pressure. MAP = mean arterial pressure. Perfusion pressure = MAP minus CVP. PEEP = positive end-expiratory pressure. SvO2 = mixed venous oxygen saturation. MFI = microvascular flow index. AU = arbitrary units. TVD = total vessel density. PPV = percentage of perfused vessels. PVD = perfused vessel density. TVD, MFI, PPV and PVD for small vessels, i.e. < 20 meter. aFor differences between T0 and T30. *P < 0.05 is considered statistically significant.