Table 2 Univariate analysis of risk factors associated to mortality in post-abdominal surgical ICU patients with infection by KPC-3 Klebsiella pneumoniae ST258 clone
No. (%) of patients | |||||
|---|---|---|---|---|---|
Variable | Dead (n = 12) | Survivors (n = 18) | Risk ratio | 95% CI | Pvalue |
Male gender | 8 (66.7) | 7 (38.9) | 1.57 | 0.84-2.92 | 0.080* |
Age, years, mean (SD) | 57.1 (17.7) | 56.0 (13.9) | 0.001 | −0.011-0.14 | 0.895^ |
LOS in ICU, days, median (IQR) | 20 (18.5-22.5) | 18.5 (13–30) | 0.005 | −0.017-0.027 | 0.644^ |
LOS in surgery ward, median (IQR) | 6.5 (3.5-8) | 8 (5–10) | −0.051 | −0.112-0.010 | 0.098^ |
Previous hospitalization | 6 (50.0) | 11 (61.1) | 0.636 | 0.13-3.03 | 0.570* |
Surgical drainage | 2 (16.7) | 12 (66.7) | 0.44 | 0.22-0.85 | 0.005* |
Underlying conditions | |||||
Smoking | 5 (41.7) | 11 (61.1) | 0.73 | 0.39-1.35 | 0.160* |
Solid tumor | 6 (50.0) | 12 (66.7) | 0.42 | 0.09-1.94 | 0.150* |
APACHE II score, mean (SD) | 24.5 (0.67) | 22.7 (1.8) | 0.147 | 0.051-0.242 | 0.004^ |
Infection type | |||||
Septicemia | 3 (25.0) | 11 (61.1) | |||
VAP | 4 (33.3) | 6 (33.3) | |||
Septicemia + VAP | 5 (41.7) | 1 ( 5.6) | 8.33 | 1.03-67.1 | 0.030* |
Intestinal carriage of KPC-Kp | 6 (50.0) | 11 (61.1) | 0.85 | 0.44-1.65 | 0.320* |
Tigecycline + colistin | |||||
High dosage | 2 (16.7) | 12 (66.7) | 0.44 | 0.22-0.85 | 0.005* |