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Table 4 Levels of evidence

From: A systematic review of the role of videolaryngoscopy in successful orotracheal intubation

1++

RCTs with a very low risk of bias (or high quality meta-analyses, systemic reviews of RCTs)

1+

RCTs with a low risk of bias (or well conducted meta-analyses, systematic reviews of RCTs)

1-

RCTs with a high risk of bias (or meta-analyses, systematic reviews or RCTs)

2++

High quality case–control or cohort studies with a very low risk of confounding/bias/chance and a high probability that the relationship is causal (or High quality systematic reviews of case–control or cohort studies)

2+

Well conducted case–control or cohort studies with a low risk of confounding/bias/chance and a moderate probability that the relationship is causal

2-

Case–control or cohort studies with a high risk of confounding/bias/chance and a significant risk that the relationship is not causal

3

Non-analytic studies, eg. Case reports, case series

4

Expert opinion

  1. Reproduced from Harbour R, Miller J. A new system for grading recommendations in evidence based guidelines. BMJ (Clinical research ed 2001;323:334-6) with permission from BMJ Publishing Group Ltd. RCTs, Randomized controlled trials.