Table 3 Cardiovascular and respiratory parameters

Baseline SBP (mmHg)^a

137.2 ± 22.1

134.2 ± 19.1

0.309

Mean% decrease of SBP^a from baseline

16.0 ± 10.5

17.2 ± 11.9

0.442

SBP decrease ≥25% from baseline (% of patients)

22.5

26.2

0.541

SBP <90 mmHg (% of patients)

4.9

13.6

0.057

Baseline heart rate (HR/min) ^a

86.0 ± 14.8

85.7 ± 15.1

0.867

Mean% decrease of HR from baseline ^a

12.5 ± 11.3

14.1 ± 12.3

0.333

HR decrease ≥25% from baseline (% of patients)

17.6

23.3

0.316

Bradycardia (% of patients)

0

1

1.000^b

Apnea

0

0

Baseline SpO₂ (%)^a

98.5 ± 1.5

97.8 ± 2.9

0.052

Greatest decline of SpO₂ from baseline ^a

6.7 ± 6.1

8.7 ± 6.9

0.026

SpO2 <90% (% of patients, any episodes)

31.4

58.3

<0.001

SpO2 <85% (% of patients, any episodes)

1.0

8.7

0.019^b