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Table 3 Histological lung injury score (LIS) of sheep subjected to pneumonectomy and injurious ventilation

From: Inhibitor of neuronal nitric oxide synthase improves gas exchange in ventilator-induced lung injury after pneumonectomy

Group Edema Neutrophil infiltration Hemorrhage Hyaline membranes Epithelial desquamation Σ
PROTV 1.0 (0.0 to 1.0) 1.0 (0.0 to 2.0) 1.0 (0.0 to 3.0) 0.0 (0.0 to 2.0) 0.0 (0.0 to 1.0) 4.0 (1.0 to 7.0)
INJV 1.0 (1.0 to 3.0) 1.0 (0.0 to 3.0) 1.0 (0.0 to 2.0) 2.0 (2.0 to 3.0) 1.0 (0.0 to 2.0) 5.0 (4.0 to 12.0)
INJV + NI 2.5 (2.0 to 3.0)‡ 3.0 (2.0 to 3.0)‡,# 2.5 (1.0 to 3.0) 1.0 (1.0 to 2.0)‡ 2.5 (2.0 to 3.0) 11.0 (11.0 to 12.0)‡
  1. Data presented as the median (minimum to maximum). Protectively ventilated group (PROTV; n = 5), injuriously ventilated group (INJV; n = 5), injuriously ventilated group treated with intravenously infused 7-nitroindazole (INJV + NI; n = 5).
  2. ‡ P < 0.05 between INJV + NI and PROTV; # P < 0.05 between INJV + NI and INJV; P < 0.05 between PROTV and INJV group.