Inhibitor of neuronal nitric oxide synthase improves gas exchange in ventilator-induced lung injury after pneumonectomy

Table 2 Ventilation, blood gases and metabolic parameters in sheep subjected to pneumonectomy and injurious ventilation

Variable	Group	BL	PE	2 h	4 h	6 h	8 h
PaCO ₂ (mm Hg)	PROTV	41.9 ± 5.3	34.5 ± 2.9	37.2 ± 4.2	36.4 ± 3.5	37.4 ± 3.9	38.6 ± 6.0
	INJV	44.2 ± 3.4	42.1 ± 7.1^†	39.2 ± 6.7	45.1 ± 20.9	55.1 ± 24.9	65.8 ± 30.4^§,†,#
	INJV + NI	40.6 ± 3.2	36.2 ± 4.4	32.5 ± 5.2	35.8 ± 4.2	39.8 ± 6.7	37.1 ± 3.8
pH	PROTV	7.44 ± 0.05	7.50 ± 0.05	7.49 ± 0.05	7.49 ± 0.06	7.48 ± 0.07	7.45 ± 0.11
	INJV	7.44 ± 0.05	7.44 ± 0.07	7.45 ± 0.08	7.42 ± 0.13	7.35 ± 0.13^§,†	7.28 ± 0.17^§,†,#
	INJV + NI	7.43 ± 0.03	7.49 ± 0.06	7.51 ± 0.05	7.46 ± 0.05	7.44 ± 0.07	7.45 ± 0.06
SvO ₂ (%)	PROTV	71 ± 9	58 ± 13	72 ± 11^§	70 ± 9^§	68 ± 6	62 ± 11
	INJV	78 ± 4	62 ± 9	73 ± 9^§	74 ± 10^§	62 ± 22	46 ± 25
	INJV + NI	77 ± 7	55 ± 6	72 ± 14^§	74 ± 12^§	70 ± 10^§	59 ± 16
Hb (g/L)	PROTV	87 ± 6	87 ± 5	94 ± 13	92 ± 14	91 ± 13	85 ± 12
	INJV	88 ± 5	92 ± 6	103 ± 11^§	109 ± 13^§,†	115 ± 10^§,†,#	124 ± 15^§,†,#
	INJV + NI	81 ± 5	84 ± 9	89 ± 7	92 ± 8	94 ± 11	96 ± 10
Ppeak	PROTV	20 ± 7	42 ± 9	40 ± 9^†,‡	45 ± 16^‡	47 ± 15^†,‡	50 ± 18^†,‡
(cmH ₂ O)	INJV	17 ± 3	36 ± 4	46 ± 6^§	49 ± 5^§	57 ± 11^§	61 ± 16^§
	INJV + NI	20 ± 4	43 ± 9	55 ± 12^§	60 ± 15^§	68 ± 18^§	67 ± 18^§
C _QS	PROTV	0.53 ± 0.20	0.25 ± 0.08	0.27 ± 0.07^§	0.26 ± 0.07	0.25 ± 0.06	0.24 ± 0.05
(mL/cmH ₂ O/kg)	INJV	0.45 ± 0.05	0.21 ± 0.03	0.32 ± 0.04^§	0.30 ± 0.05^§	0.25 ± 0.05^§	0.23 ± 0.06
	INJV + NI	0.40 ± 0.09	0.26 ± 0.07	0.35 ± 0.08	0.33 ± 0.10	0.28 ± 0.07	0.27 ± 0.08

Partial pressure of carbon dioxide in arterial blood (PaCO₂), mixed venous oxygen saturation (SvO₂), hemoglobin concentration (Hb), peak airway pressure (Ppeak), quasi static compliance (C_QS). Baseline (BL), pneumonectomy (PE), 2 h – 8 h are time points in hours after PE. Data are presented as the mean ± standard deviation. Protectively ventilated group (PROTV; n = 8), injuriously ventilated group (INJV; n = 8), injuriously ventilated group treated with intravenously infused 7-nitroindazole (INJV + NI; n = 8). ^§ P < 0.05 within group in comparison with the 0 hours; ^† P < 0.05 between PROTV and INJV groups; ^‡ P < 0.05 between INJV + NI and PROTV groups; ^# P < 0.05 between INJV + NI and INJV groups.

ISSN: 1471-2253