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Table 2 Ventilation, blood gases and metabolic parameters in sheep subjected to pneumonectomy and injurious ventilation

From: Inhibitor of neuronal nitric oxide synthase improves gas exchange in ventilator-induced lung injury after pneumonectomy

Variable Group BL PE 2 h 4 h 6 h 8 h
PaCO 2 (mm Hg) PROTV 41.9 ± 5.3 34.5 ± 2.9 37.2 ± 4.2 36.4 ± 3.5 37.4 ± 3.9 38.6 ± 6.0
  INJV 44.2 ± 3.4 42.1 ± 7.1 39.2 ± 6.7 45.1 ± 20.9 55.1 ± 24.9 65.8 ± 30.4§,†,#
  INJV + NI 40.6 ± 3.2 36.2 ± 4.4 32.5 ± 5.2 35.8 ± 4.2 39.8 ± 6.7 37.1 ± 3.8
pH PROTV 7.44 ± 0.05 7.50 ± 0.05 7.49 ± 0.05 7.49 ± 0.06 7.48 ± 0.07 7.45 ± 0.11
  INJV 7.44 ± 0.05 7.44 ± 0.07 7.45 ± 0.08 7.42 ± 0.13 7.35 ± 0.13§,† 7.28 ± 0.17§,†,#
  INJV + NI 7.43 ± 0.03 7.49 ± 0.06 7.51 ± 0.05 7.46 ± 0.05 7.44 ± 0.07 7.45 ± 0.06
SvO 2 (%) PROTV 71 ± 9 58 ± 13 72 ± 11§ 70 ± 9§ 68 ± 6 62 ± 11
  INJV 78 ± 4 62 ± 9 73 ± 9§ 74 ± 10§ 62 ± 22 46 ± 25
  INJV + NI 77 ± 7 55 ± 6 72 ± 14§ 74 ± 12§ 70 ± 10§ 59 ± 16
Hb (g/L) PROTV 87 ± 6 87 ± 5 94 ± 13 92 ± 14 91 ± 13 85 ± 12
  INJV 88 ± 5 92 ± 6 103 ± 11§ 109 ± 13§,† 115 ± 10§,†,# 124 ± 15§,†,#
  INJV + NI 81 ± 5 84 ± 9 89 ± 7 92 ± 8 94 ± 11 96 ± 10
Ppeak PROTV 20 ± 7 42 ± 9 40 ± 9†,‡ 45 ± 16 47 ± 15†,‡ 50 ± 18†,‡
(cmH 2 O) INJV 17 ± 3 36 ± 4 46 ± 6§ 49 ± 5§ 57 ± 11§ 61 ± 16§
  INJV + NI 20 ± 4 43 ± 9 55 ± 12§ 60 ± 15§ 68 ± 18§ 67 ± 18§
C QS PROTV 0.53 ± 0.20 0.25 ± 0.08 0.27 ± 0.07§ 0.26 ± 0.07 0.25 ± 0.06 0.24 ± 0.05
(mL/cmH 2 O/kg) INJV 0.45 ± 0.05 0.21 ± 0.03 0.32 ± 0.04§ 0.30 ± 0.05§ 0.25 ± 0.05§ 0.23 ± 0.06
  INJV + NI 0.40 ± 0.09 0.26 ± 0.07 0.35 ± 0.08 0.33 ± 0.10 0.28 ± 0.07 0.27 ± 0.08
  1. Partial pressure of carbon dioxide in arterial blood (PaCO2), mixed venous oxygen saturation (SvO2), hemoglobin concentration (Hb), peak airway pressure (Ppeak), quasi static compliance (CQS). Baseline (BL), pneumonectomy (PE), 2 h – 8 h are time points in hours after PE. Data are presented as the mean ± standard deviation. Protectively ventilated group (PROTV; n = 8), injuriously ventilated group (INJV; n = 8), injuriously ventilated group treated with intravenously infused 7-nitroindazole (INJV + NI; n = 8). § P < 0.05 within group in comparison with the 0 hours; P < 0.05 between PROTV and INJV groups; P < 0.05 between INJV + NI and PROTV groups; # P < 0.05 between INJV + NI and INJV groups.