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Table 1 Hemodynamic and volumetric variables in sheep subjected to pneumonectomy and injurious ventilation

From: Inhibitor of neuronal nitric oxide synthase improves gas exchange in ventilator-induced lung injury after pneumonectomy

Variable

Group

BL

PE

2 h

4 h

6 h

8 h

PVPI

PROTV

0.03 ± 0.01

0.02 ± 0.00

0.02 ± 0.00

0.02 ± 0.01

0.02 ± 0.01

0.02 ± 0.01†

 

INJV

0.04 ± 0.01

0.02 ± 0.01

0.03 ± 0.01

0.02 ± 0.01

0.04 ± 0.02

0.07 ± 0.03§

 

INJV + NI

0.04 ± 0.02

0.03 ± 0.02

0.03 ± 0.03

0.03 ± 0.03

0.04 ± 0.05§

0.06 ± 0.05§

PBVI (mL/m 2 )

PROTV

285 ± 127

196 ± 74

210 ± 75

215 ± 62

206 ± 69

210 ± 65

 

INJV

229 ± 38

183 ± 49

179 ± 54

208 ± 31

181 ± 41

162 ± 47

 

INJV + NI

208 ± 42

163 ± 55

171 ± 30

173 ± 25

181 ± 47

162 ± 38

GEDVI

PROTV

602 ± 127

557 ± 175

537 ± 138

539 ± 144

567 ± 124

612 ± 144

(mL/m 2 )

INJV

603 ± 72

532 ± 70

527 ± 78

573 ± 65

598 ± 111§

622 ± 160§

 

INJV + NI

615 ± 80

540 ± 48

594 ± 118

553 ± 66

617 ± 50§

590 ± 65§

CI

PROTV

3.4 ± 0.8

3.9 ± 1.9

4.5 ± 1.7

4.4 ± 1.7

4.7 ± 1.4

4.6 ± 1.6

(L/min/m 2 )

INJV

3.6 ± 0.5

3.7 ± 0.7

4.4 ± 1.1

5.2 ± 1.2§

5.2 ± 1.3§

4.9 ± 1.7

 

INJV + NI

4.1 ± 0.7

2.9 ± 0.5

3.8 ± 0.6§

3.7 ± 0.6§

3.9 ± 0.6§

3.5 ± 0.6

PAP (mm Hg)

PROTV

12 ± 2

19 ± 5

20 ± 3

21 ± 4

20 ± 4

22 ± 7

 

INJV

12 ± 3

18 ± 5

21 ± 4§

25 ± 5§

28 ± 6§,†

31 ± 6§,†

 

INJV + NI

12 ± 2

17 ± 2

20 ± 4§

23 ± 7§

26 ± 6§

28 ± 6§

PAOP (mm Hg)

PROTV

6 ± 3

6 ± 3

6 ± 3

9 ± 4§

9 ± 4§

8 ± 4§

 

INJV

5 ± 2

8 ± 3

8 ± 3

12 ± 4§

14 ± 5§,†

16 ± 4§,†,#

 

INJV + NI

6 ± 2

8 ± 3

10 ± 3§

9 ± 4

11 ± 4§

10 ± 3§

SVRI (dyn sec/cm -5 /m 2 )

PROTV

2096 ± 641

2757 ± 878

2001 ± 749§

2039 ± 923§

1851 ± 877§

1889 ± 872§

 

INJV

2278 ± 418

2389 ± 572

2021 ± 592

1682 ± 491§

1547 ± 480§

1717 ± 514§

 

INJV + NI

2034 ± 371

2743 ± 571

2352 ± 647

2198 ± 562

2299 ± 432

2332 ± 538

PVRI (dyn sec/cm -5 /m 2 )

PROTV

129 ± 53

286 ± 104

258 ± 123

247 ± 146

220 ± 81§

253 ± 136

 

INJV

164 ± 73

231 ± 34

238 ± 54

212 ± 51

233 ± 78

276 ± 125

 

INJV + NI

128 ± 56

266 ± 103

242 ± 72

299 ± 130

333 ± 155

426 ± 122‡

  1. Pulmonary vascular permeability index (PVPI), cardiac index (CI), pulmonary blood volume index (PBVI), global end-diastolic volume index (GEDVI), pulmonary artery pressure (PAP), pulmonary artery occlusion pressure (PAOP), systemic vascular resistance index (SVRI) pulmonary vascular resistance index (PVRI). Baseline (BL), thoracotomy (TT), pneumonectomy (PE), 2 h – 8 h are time points in hours after PE. Data are presented as the mean ± standard deviation. Protectively ventilated group (PROTV; n = 8), injuriously ventilated group (INJV; n = 8), injuriously ventilated group treated with intravenously infused 7-nitroindazole (INJV + NI; n = 8). § P < 0.05 within group in comparison with PE; † P < 0.05 between PROTV and INJV groups; ‡ P < 0.05 between INJV + NI and PROTV groups; # P < 0.05 between INJV + NI and INJV groups.