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Table 1 Hemodynamic and volumetric variables in sheep subjected to pneumonectomy and injurious ventilation

From: Inhibitor of neuronal nitric oxide synthase improves gas exchange in ventilator-induced lung injury after pneumonectomy

Variable Group BL PE 2 h 4 h 6 h 8 h
PVPI PROTV 0.03 ± 0.01 0.02 ± 0.00 0.02 ± 0.00 0.02 ± 0.01 0.02 ± 0.01 0.02 ± 0.01
  INJV 0.04 ± 0.01 0.02 ± 0.01 0.03 ± 0.01 0.02 ± 0.01 0.04 ± 0.02 0.07 ± 0.03§
  INJV + NI 0.04 ± 0.02 0.03 ± 0.02 0.03 ± 0.03 0.03 ± 0.03 0.04 ± 0.05§ 0.06 ± 0.05§
PBVI (mL/m 2 ) PROTV 285 ± 127 196 ± 74 210 ± 75 215 ± 62 206 ± 69 210 ± 65
  INJV 229 ± 38 183 ± 49 179 ± 54 208 ± 31 181 ± 41 162 ± 47
  INJV + NI 208 ± 42 163 ± 55 171 ± 30 173 ± 25 181 ± 47 162 ± 38
GEDVI PROTV 602 ± 127 557 ± 175 537 ± 138 539 ± 144 567 ± 124 612 ± 144
(mL/m 2 ) INJV 603 ± 72 532 ± 70 527 ± 78 573 ± 65 598 ± 111§ 622 ± 160§
  INJV + NI 615 ± 80 540 ± 48 594 ± 118 553 ± 66 617 ± 50§ 590 ± 65§
CI PROTV 3.4 ± 0.8 3.9 ± 1.9 4.5 ± 1.7 4.4 ± 1.7 4.7 ± 1.4 4.6 ± 1.6
(L/min/m 2 ) INJV 3.6 ± 0.5 3.7 ± 0.7 4.4 ± 1.1 5.2 ± 1.2§ 5.2 ± 1.3§ 4.9 ± 1.7
  INJV + NI 4.1 ± 0.7 2.9 ± 0.5 3.8 ± 0.6§ 3.7 ± 0.6§ 3.9 ± 0.6§ 3.5 ± 0.6
PAP (mm Hg) PROTV 12 ± 2 19 ± 5 20 ± 3 21 ± 4 20 ± 4 22 ± 7
  INJV 12 ± 3 18 ± 5 21 ± 4§ 25 ± 5§ 28 ± 6§,† 31 ± 6§,†
  INJV + NI 12 ± 2 17 ± 2 20 ± 4§ 23 ± 7§ 26 ± 6§ 28 ± 6§
PAOP (mm Hg) PROTV 6 ± 3 6 ± 3 6 ± 3 9 ± 4§ 9 ± 4§ 8 ± 4§
  INJV 5 ± 2 8 ± 3 8 ± 3 12 ± 4§ 14 ± 5§,† 16 ± 4§,†,#
  INJV + NI 6 ± 2 8 ± 3 10 ± 3§ 9 ± 4 11 ± 4§ 10 ± 3§
SVRI (dyn sec/cm -5 /m 2 ) PROTV 2096 ± 641 2757 ± 878 2001 ± 749§ 2039 ± 923§ 1851 ± 877§ 1889 ± 872§
  INJV 2278 ± 418 2389 ± 572 2021 ± 592 1682 ± 491§ 1547 ± 480§ 1717 ± 514§
  INJV + NI 2034 ± 371 2743 ± 571 2352 ± 647 2198 ± 562 2299 ± 432 2332 ± 538
PVRI (dyn sec/cm -5 /m 2 ) PROTV 129 ± 53 286 ± 104 258 ± 123 247 ± 146 220 ± 81§ 253 ± 136
  INJV 164 ± 73 231 ± 34 238 ± 54 212 ± 51 233 ± 78 276 ± 125
  INJV + NI 128 ± 56 266 ± 103 242 ± 72 299 ± 130 333 ± 155 426 ± 122
  1. Pulmonary vascular permeability index (PVPI), cardiac index (CI), pulmonary blood volume index (PBVI), global end-diastolic volume index (GEDVI), pulmonary artery pressure (PAP), pulmonary artery occlusion pressure (PAOP), systemic vascular resistance index (SVRI) pulmonary vascular resistance index (PVRI). Baseline (BL), thoracotomy (TT), pneumonectomy (PE), 2 h – 8 h are time points in hours after PE. Data are presented as the mean ± standard deviation. Protectively ventilated group (PROTV; n = 8), injuriously ventilated group (INJV; n = 8), injuriously ventilated group treated with intravenously infused 7-nitroindazole (INJV + NI; n = 8). § P < 0.05 within group in comparison with PE; P < 0.05 between PROTV and INJV groups; P < 0.05 between INJV + NI and PROTV groups; # P < 0.05 between INJV + NI and INJV groups.