Arterial oxygen partial pressure (PaO
), saturation (SaO
) and venous admixture in anesthetized sheep. Baseline (BL), after right-sided thoracotomy (TT) and after pneumonectomy (PE = time, 0 hour) subsequently followed by injurious ventilation. 2 h – 8 h are time points in hours after PE. 7-nitroindazole (NI) was administered from time 2 h and throughout. Protectively ventilated group (PROTV; n = 8), injuriously ventilated group (INJV; n = 8), injuriously ventilated group treated with intravenously infused 7-nitroindazole (INJV + NI; n = 8). Data presented as the mean ± standard deviation. § P < 0.05 within group in comparison with PE; † P < 0.05 between PROTV and INJV, # P < 0.05 between INJV and INJV + NI groups.