Extravascular lung water index (EVLWI) in anesthetized sheep. Baseline (BL), after right-sided thoracotomy and pneumonectomy (PE = time 0 hour) subsequently followed by injurious ventilation. 2 h – 8 h are time points in hours after PE. 7-nitroindazole (NI) was administered from time 2 h and throughout. Protectively ventilated group (PROTV; n = 8), injuriously ventilated group (INJV; n = 8), injuriously ventilated group treated with intravenously infused 7-nitroindazole (INJV + NI; n = 8). Data are presented as the mean ± standard deviation. § P < 0.05 within group in comparison with PE; † P < 0.05 between PROTV and INJV group.