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Table 2 Changes in mean pulmonary artery pressure at different time points during the ventilation protocol and histology scores.

From: Metabolic acidosis may be as protective as hypercapnic acidosis in an ex-vivo model of severe ventilator-induced lung injury: a pilot study

Variables

HPC n = 9

HPRA n = 10

HPMA n = 9

LPC n = 10

LPRA n = 9

LPMA n = 10

dPAP20, mmHg

8.5 ± 2.3

3,9 ± 1,9

16.7 ± 3.1

0.7 ± 1.0

0.2 ± 0.5

2.7 ± 1.7

dPAP40, mmHg

11.4 ± 2.7

10,8 ± 3.5

35.4 ± 9.9

3.2 ± 1.0

0.8 ± 0.5

5.1 ± 2.1

  1. All values are expressed as mean ± SEM
  2. n = preparations included in the study
  3. HPC: high-pressure control (normocapnic); HPRA: high-pressure respiratory acidosis (hypercapnic); HPMA: high-pressure metabolic acidosis; LPC: low-pressure control (normocapnic); LPRA: low-pressure respiratory acidosis (hypercapnic); LPMA: low-pressure metabolic acidosis; dKf: difference in ultrafiltration coefficient before and after the 1-hr ventilation-perfusion protocol; dPAP20: difference in mean pulmonary artery pressure after 20 min of ventilation; dPAP40: difference in mean pulmonary artery pressure after 40 min of ventilation-perfusion