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Table 1 Characteristics of animals and heart-lungs preparations at baseline

From: Metabolic acidosis may be as protective as hypercapnic acidosis in an ex-vivo model of severe ventilator-induced lung injury: a pilot study

Variables

HPC n = 10

HPRA n = 10

HPMA n = 10

LPC n = 10

LPRA n = 10

LPMA n = 10

Pvalue

Animal weight, kg

3.3 ± 1.0

3.2 ± 1.0

3,0 ± 0.9

3,2 ± 0.8

3,2 ± 0.8

3.2 ± 0.8

0.42

 

Lung weight, g

19.6 ± 1.6

20.6 ± 1.2

21.4 ± 1.2

22.0 ± 1.2

20.4 ± 1.0

21.3 ± 1.4

0.79

 

Ischemic time , min

37.2 ± 2.3

34.0 ± 2.6

29.7 ± 1.4

33.2 ± 1.5

32.2 ± 2.4

30.4 ± 1.0

0.11

 

pH

7.42 ± 0.02

7.42 ± 0.01

7.43 ± 0.02

7.43 ± 0.01

7.41 ± 0.02

7.58 ± 0.15

0.56

 

pCO2, mmHg

35.9 ± 4.2

37.2 ± 2.0

37.3 ± 3.5

38.1 ± 2.2

39.1 ± 1.7

36.7 ± 1.4

0.47

 

pO2, mmHg

175.3 ± 15.2

159.4 ± 7.4

168.1 ± 16.4

157.3 ± 14.5

218.0 ± 30.3

156.3 ± 10.5

0.11

 

T, °C

36.2 ± 0.1

36.4 ± 0.1

36.1 ± 0.1

36.3 ± 0.1

36.3 ± 0.1

36.3 ± 0.1

0.77

 

Mean pulmonary artery pressure, mmHg

16.7 ± 0.9

15.2 ± 1.8

18.3 ± 1.3

16.7 ± 2,3

14.0 ± 1.90

19.6 ± 1.2

0.02

 

Ultrafiltration coefficient, Kfbase, g/min/mm Hg/100 g

0.36 ± 0.18

0.19 ± 0.06

0.24 ± 0.05

0.60 ± 0.39

0.25 ± 0.04

0.20 ± 0.03

0.54

 
  1. All values expressed as mean ± SEM.
  2. No statistically significant differences were observed
  3. HPC: high-pressure control (normocapnic); HPRA: high-pressure respiratory acidosis (hypercapnic); HPMA: high-pressure metabolic acidosis; LPC: low-pressure control (normocapnic); LPRA: low-pressure respiratory acidosis (hypercapnic); LPMA: low-pressure metabolic acidosis