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Figure 2 | BMC Anesthesiology

Figure 2

From: Esmolol modulates inhibitory neurotransmission in the substantia gelatinosa of the spinal trigeminal nucleus of the rat

Figure 2

Effects of β receptor agonists on the effect of esmolol and the effects of another beta antagonist, landiolol, on synaptic inhibitory transmission in the caudal part of the spinal trigeminal nucleus (Sp5c) neurons. (A and B) Top: the membrane current recording of a neuron of the Sp5c in the absence (A) and presence (B) of 10-min prior administration of isoproterenol (100 μM). Recordings with "CsCl-based" internal solution. Esmolol was applied at the horizontal bar. Bottom of A and B: time-expanded continuous traces taken at points 1 and 2 in the top trace. (C) Summary of the effect of esmolol on mIPSC frequency in the absence (open circles; filled bar) and presence (filled circles; open bar) of isoproterenol. The bars show the average values. *, P < 0.05; Mann Whitney's U-test. NS, not significantly different; vs. pre-esmolol values. Each circle represents the data from one neuron (n = 6 neurons). (D) Top: the membrane current recording of a neuron of Sp5c using "CsCl-based" internal solution. Landiolol was applied at the horizontal bar. Bottom: time-expanded continuous traces taken at points 1 and 2 in the top trace. (E) Concentration-response relationship between landiolol and the changes in mIPSC frequency. The number of neurons used to estimate the mean values was 12 (control); 4 (5 μM); 4 (50 μM); 4 (100 μM); 10 (500 μM); 4 (1500 μM). Mann-Whitney's U test; vs. control (no drug application). The horizontal broken line indicates the control values (100%).

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