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Table 4 Risk of headache with 5-HT3 receptor antagonists

From: Treatment of established postoperative nausea and vomiting: a quantitative systematic review

       

Number with

  
 

5-HT3 receptor antagonist (mg)

 

Event rate

   

Relative risk

References

       

headache/Total number

  

Dose

Dolasetron

Granisetron

Tropisetron

Ondansetron

Active

Placebo

Active

Placebo

95% confidence interval

 

Low:

12.5

0.1

0.5

1

7.7%

10.4%

41/531

55/531

0.75 (0.51 to 1.10)

[16][19][34][40][41]

Medium:

25, 50

1

2

4

9.3%

9.3%

71/765

55/591

1.09 (0.78 to 1.52)

[16][19][34][40][41][45]

High:

100

3

5

8

13.3%

9.9%

74/556

56/567

1.36 (0.98 to 1.88)

[16][19][34][40][41][42]

  1. Doses have been grouped arbitrarily into "low", "medium", and "high"; these groups do not represent equipotent doses.
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BMC Anesthesiology

ISSN: 1471-2253

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