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Table 4 Risk of headache with 5-HT3 receptor antagonists

From: Treatment of established postoperative nausea and vomiting: a quantitative systematic review

        Number with   
  5-HT3 receptor antagonist (mg)   Event rate     Relative risk References
        headache/Total number   
Dose Dolasetron Granisetron Tropisetron Ondansetron Active Placebo Active Placebo 95% confidence interval  
Low: 12.5 0.1 0.5 1 7.7% 10.4% 41/531 55/531 0.75 (0.51 to 1.10) [16][19][34][40][41]
Medium: 25, 50 1 2 4 9.3% 9.3% 71/765 55/591 1.09 (0.78 to 1.52) [16][19][34][40][41][45]
High: 100 3 5 8 13.3% 9.9% 74/556 56/567 1.36 (0.98 to 1.88) [16][19][34][40][41][42]
  1. Doses have been grouped arbitrarily into "low", "medium", and "high"; these groups do not represent equipotent doses.