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Table 3 Efficacy data

From: Treatment of established postoperative nausea and vomiting: a quantitative systematic review

  Early success Late success
  Success rate Relative Risk Number Needed To Treat Ref Success rate Relative Risk Number Needed To Treat Ref
  Active Control* (95% confidence interval) (95% confidence interval) Active Control*   (95% confidence interval) (95% confidence interval)  
Prevention of further nausea
Granisetron           
0.1 mg 40% 17% 2.41 (1.56 to 3.73) 4.3 (3.0 to 7.9) [41] 27% 13% 2.08 (1.22 to 3.53) 7.3 (4.3 to 24) [41]
1 mg 41% 17% 2.45 (1.59 to 3.79) 4.2 (2.9 to 7.4) [41] 30% 13% 2.35 (1.41 to 3.93) 5.8 (3.7 to 13) [41]
3 mg 42% 17% 2.56 (1.66 to 3.95) 3.9 (2.7 to 6.6) [41] 37% 13% 2.88 (1.75 to 4.75) 4.2 (2.9 to 7.2) [41]
Tropisetron           
0.5 mg 58% 45% 1.29 (0.94 to 1.75) 7.7 (3.5 to -38) [34] 43% 34% 1.27 (0.85 to 1.90) 11 (4.1 to -16) [34]
2 mg 56% 45% 1.24 (0.91 to 1.69) 9.3 (3.8 to -21) [34] 45% 34% 1.33 (0.90 to 1.98) 8.9 (3.8 to -25) [34]
5 mg 56% 45% 1.24 (0.91 to 1.69) 9.3 (3.8 to -21) [34] 46% 34% 1.37 (0.93 to 2.03) 8.0 (3.6 to -37) [34]
Ondansetron           
8 mg 78% 28% 2.80 (1.28 to 6.14) 2.0 (1.3 to 4.6) [44] no data
Propofol           
any dose 36% 25% 1.44 (0.49 to 4.22) 9.0 (2.5 to -5.6) [46] no data
Other drugs           
GR205171 25 mg 56% 22% 2.50 (0.96 to 6.52) 3.0 (1.6 to 29) [33] no data
Isopropyl alcohol 90% 42% 2.14 (1.24 to 3.69) 2.1 (1.4 to 4.5) [31] no data
Prevention of further vomiting
Dolasetron           
12.5 mg 55% 27% 2.03 (1.46 to 2.82) 3.6 (2.5 to 6.1) [19] 32% 11% 2.88 (1.83 to 4.54) 4.8 (3.5 to 7.8) [19][40]
25 mg 50% 27% 1.85 (1.31 to 2.60) 4.3 (2.8 to 9.0) [19] 28% 11% 2.54 (1.59 to 4.04) 6.0 (4.1 to 11) [19][40]
50 mg 48% 27% 1.77 (1.26 to 2.50) 4.7 (3.0 to 11) [19] 32% 11% 2.93 (1.86 to 4.61) 4.8 (3.5 to 7.7) [19][40]
100 mg 51% 27% 1.86 (1.33 to 2.61) 4.3 (2.8 to 8.5) [19] 28% 11% 2.54 (1.60 to 4.04) 5.9 (4.1 to 11) [19][40]
Granisetron           
0.1 mg 53% 26% 2.02 (1.45 to 2.80) 3.7 (2.6 to 6.5) [41] 38% 20% 1.96 (1.30 to 2.95) 5.3 (3.4 to 13) [41]
1 mg 58% 26% 2.20 (1.60 to 3.03) 3.2 (2.3 to 4.9) [41] 46% 20% 2.35 (1.59 to 3.47) 3.8 (2.7 to 6.5) [41]
3 mg 60% 26% 2.28 (1.66 to 3.13) 3.0 (2.2 to 4.5) [41] 49% 20% 2.50 (1.69 to 3.68) 3.4 (2.5 to 5.5) [41]
Tropisetron           
0.5 mg 70% 45% 1.54 (1.16 to 2.05) 4.1 (2.5 to 10) [34] 52% 29% 1.82 (1.20 to 2.75) 4.3 (2.6 to 12) [34]
2 mg 76% 45% 1.68 (1.28 to 2.21) 3.2 (2.2 to 6.1) [34] 58% 29% 2.01 (1.35 to 3.00) 3.5 (2.3 to 7.1) [34]
5 mg 74% 45% 1.62 (1.23 to 2.14) 3.5 (2.3 to 7.4) [34] 60% 29% 2.10 (1.41 to 3.12) 3.2 (2.2 to 6.0) [34]
Ondansetron           
0.1 mg 22% 16% 1.40 (0.50 to 3.95) 16 (4.0 to -7.8) [43] 16% 16% 1.00 (0.32 to 3.12) ∞ (5.6 to -5.6) [43]
1 mg 57% 30% 1.88 (1.39 to 2.55) 3.7 (2.6 to 6.6) [16] 40% 20% 2.04 (1.51 to 2.75) 4.8 (3.5 to 7.9) [16][17]
4 mg 57% 27% 2.10 (1.58 to 2.79) 3.3 (2.5 to 5.1) [16][43] 45% 19% 2.29 (1.73 to 3.02) 4.0 (3.0 to 5.7) [16][17][43]
8 mg 59% 32% 1.84 (1.45 to 2.35) 3.7 (2.7 to 5.8) [16][42][44] 44% 20% 2.23 (1.66 to 3.00) 4.1 (3.1 to 6.2) [16][17]
16 mg 54% 16% 3.43 (1.43 to 8.23) 2.6 (1.7 to 6.4) [43] 50% 16% 3.20 (1.32 to 7.76) 2.9 (1.8 to 8.3) [43]
0.1 mg/kg 78% 34% 2.27 (1.83 to 2.81) 2.3 (1.9 to 2.9) [30] 53% 17% 3.14 (2.21 to 4.48) 2.8 (2.2 to 3.7) [30]
Propofol           
any dose 85% 76% 1.18 (1.01 to 1.37) 10 (4.6 to -47) [35][46][47] 53% 57% 0.88 (0.64 to 1.22) -26 (7.7 to -4.9) [35][47]
Other drugs           
GR205171 25 mg 78% 28% 2.80 (1.28 to 6.14) 2.0 (1.3 to 4.6) [33] no data
Isopropyl alcohol 35% 11% 3.33 (0.79 to 14.0) 4.1 (2 to -174) [31] no data
Midazolam 90% 30% 3.00 (1.14 to 7.91) 1.7 (1.1 to 3.8) [48] no data
  1. *control = placebo, except in propofol trials where control = intralipid; ∞ = infinity (absolute risk reduction = 0)