Table 3 Efficacy data

40%

17%

2.41 (1.56 to 3.73)

4.3 (3.0 to 7.9)

[41]

27%

13%

2.08 (1.22 to 3.53)

7.3 (4.3 to 24)

[41]

41%

17%

2.45 (1.59 to 3.79)

4.2 (2.9 to 7.4)

[41]

30%

13%

2.35 (1.41 to 3.93)

5.8 (3.7 to 13)

[41]

42%

17%

2.56 (1.66 to 3.95)

3.9 (2.7 to 6.6)

[41]

37%

13%

2.88 (1.75 to 4.75)

4.2 (2.9 to 7.2)

[41]

58%

45%

1.29 (0.94 to 1.75)

7.7 (3.5 to -38)

[34]

43%

34%

1.27 (0.85 to 1.90)

11 (4.1 to -16)

[34]

56%

45%

1.24 (0.91 to 1.69)

9.3 (3.8 to -21)

[34]

45%

34%

1.33 (0.90 to 1.98)

8.9 (3.8 to -25)

[34]

56%

45%

1.24 (0.91 to 1.69)

9.3 (3.8 to -21)

[34]

46%

34%

1.37 (0.93 to 2.03)

8.0 (3.6 to -37)

[34]

78%

28%

2.80 (1.28 to 6.14)

2.0 (1.3 to 4.6)

[44]

no data

36%

25%

1.44 (0.49 to 4.22)

9.0 (2.5 to -5.6)

[46]

no data

56%

22%

2.50 (0.96 to 6.52)

3.0 (1.6 to 29)

[33]

no data

90%

42%

2.14 (1.24 to 3.69)

2.1 (1.4 to 4.5)

[31]

no data

55%

27%

2.03 (1.46 to 2.82)

3.6 (2.5 to 6.1)

[19]

32%

11%

2.88 (1.83 to 4.54)

4.8 (3.5 to 7.8)

[19][40]

50%

27%

1.85 (1.31 to 2.60)

4.3 (2.8 to 9.0)

[19]

28%

11%

2.54 (1.59 to 4.04)

6.0 (4.1 to 11)

[19][40]

48%

27%

1.77 (1.26 to 2.50)

4.7 (3.0 to 11)

[19]

32%

11%

2.93 (1.86 to 4.61)

4.8 (3.5 to 7.7)

[19][40]

51%

27%

1.86 (1.33 to 2.61)

4.3 (2.8 to 8.5)

[19]

28%

11%

2.54 (1.60 to 4.04)

5.9 (4.1 to 11)

[19][40]

53%

26%

2.02 (1.45 to 2.80)

3.7 (2.6 to 6.5)

[41]

38%

20%

1.96 (1.30 to 2.95)

5.3 (3.4 to 13)

[41]

58%

26%

2.20 (1.60 to 3.03)

3.2 (2.3 to 4.9)

[41]

46%

20%

2.35 (1.59 to 3.47)

3.8 (2.7 to 6.5)

[41]

60%

26%

2.28 (1.66 to 3.13)

3.0 (2.2 to 4.5)

[41]

49%

20%

2.50 (1.69 to 3.68)

3.4 (2.5 to 5.5)

[41]

70%

45%

1.54 (1.16 to 2.05)

4.1 (2.5 to 10)

[34]

52%

29%

1.82 (1.20 to 2.75)

4.3 (2.6 to 12)

[34]

76%

45%

1.68 (1.28 to 2.21)

3.2 (2.2 to 6.1)

[34]

58%

29%

2.01 (1.35 to 3.00)

3.5 (2.3 to 7.1)

[34]

74%

45%

1.62 (1.23 to 2.14)

3.5 (2.3 to 7.4)

[34]

60%

29%

2.10 (1.41 to 3.12)

3.2 (2.2 to 6.0)

[34]

22%

16%

1.40 (0.50 to 3.95)

16 (4.0 to -7.8)

[43]

16%

16%

1.00 (0.32 to 3.12)

∞ (5.6 to -5.6)

[43]

57%

30%

1.88 (1.39 to 2.55)

3.7 (2.6 to 6.6)

[16]

40%

20%

2.04 (1.51 to 2.75)

4.8 (3.5 to 7.9)

[16][17]

57%

27%

2.10 (1.58 to 2.79)

3.3 (2.5 to 5.1)

[16][43]

45%

19%

2.29 (1.73 to 3.02)

4.0 (3.0 to 5.7)

[16][17][43]

59%

32%

1.84 (1.45 to 2.35)

3.7 (2.7 to 5.8)

[16][42][44]

44%

20%

2.23 (1.66 to 3.00)

4.1 (3.1 to 6.2)

[16][17]

54%

16%

3.43 (1.43 to 8.23)

2.6 (1.7 to 6.4)

[43]

50%

16%

3.20 (1.32 to 7.76)

2.9 (1.8 to 8.3)

[43]

78%

34%

2.27 (1.83 to 2.81)

2.3 (1.9 to 2.9)

[30]

53%

17%

3.14 (2.21 to 4.48)

2.8 (2.2 to 3.7)

[30]

85%

76%

1.18 (1.01 to 1.37)

10 (4.6 to -47)

[35][46][47]

53%

57%

0.88 (0.64 to 1.22)

-26 (7.7 to -4.9)

[35][47]

78%

28%

2.80 (1.28 to 6.14)

2.0 (1.3 to 4.6)

[33]

no data

35%

11%

3.33 (0.79 to 14.0)

4.1 (2 to -174)

[31]

no data

90%

30%

3.00 (1.14 to 7.91)

1.7 (1.1 to 3.8)

[48]

no data