Cocktail sedation containing propofol versus conventional sedation for ERCP: a prospective, randomized controlled study
© Angsuwatcharakon et al.; licensee BioMed Central Ltd. 2012
Received: 26 December 2011
Accepted: 3 August 2012
Published: 9 August 2012
ERCP practically requires moderate to deep sedation controlled by a combination of benzodiazepine and opiod. Propofol as a sole agent may cause oversedation. A combination (cocktail) of infused propofol, meperidine, and midazolam can reduce the dosage of propofol and we hypothesized that it might decrease the risk of oversedation. We prospectively compare the efficacy, recovery time, patient satisfactory, and side effects between cocktail and conventional sedations in patients undergoing ERCP.
ERCP patients were randomized into 2 groups; the cocktail group (n = 103) and the controls (n = 102). For induction, a combination of 25 mg of meperidine and 2.5 mg of midazolam were administered in both groups. In the cocktail group, a bolus dose of propofol 1 mg/kg was administered and continuously infused. In the controls, 25 mg of meperidine or 2.5 mg/kg of midazolam were titrated to maintain the level of sedation.
In the cocktail group, the average administration rate of propofol was 6.2 mg/kg/hr. In the control group; average weight base dosage of meperidine and midazolam were 1.03 mg/kg and 0.12 mg/kg, respectively. Recovery times and patients’ satisfaction scores in the cocktail and control groups were 9.67 minutes and 12.89 minutes (P = 0.045), 93.1and 87.6 (P <0.001), respectively. Desaturation rates in the cocktail and conventional groups were 58.3% and 31.4% (P <0.001), respectively. All desaturations were corrected with temporary oxygen supplementation without the need for scope removal.
Cocktail sedation containing propofol provides faster recovery time and better patients’ satisfaction for patients undergoing ERCP. However, mild degree of desaturation may still develop.
KeywordsCocktail sedation containing propofol Meperidine Midazolam ERCP
In order to facilitate a high success rate and avoids patients’ discomfort from a long procedure, endoscopic retrograde cholangiopancreatography (ERCP) requires a good moderate to deep level of sedation [1, 2]. Propofol has been increasingly used for sedation in many gastrointestinal procedures including ERCP because it has a shorter both half-life and results in a shorter recovery time than conventional sedation (opioid and/or benzodiazepine)[3–6]. In addition, it can be safely administered by non-anesthetist e.g. well-trained nurses with or without endoscopist’s advice [7–9]. Because of its narrow therapeutic window, the level of conscious sedation can easily go deeper from moderately deep sedation to near general anesthesia. Therefore, propofol as a sole agent can cause oversedation and apnea [4, 10, 11]. A combination of benzodiazepine, and propofol has been shown to reduce the dose requirement of propofol while maintaining comparable efficacy [12, 13]. This in turn may reduce the risk of oversedation by propofol [14, 15]. Moreover, at a moderate sedation level, propofol does not have analgesic property, patients undergoing ERCP under propofol sedation alone could be suffered from pain. A cocktail regimen containing meperidine/midazolam and propofol may add additive analgesic effect during ERCP. Furthermore, administering propofol by infusion pump provides constant plasma level of propofol and may reduce adverse effect of overdosing by a bolus dose. However, data for cocktail sedation in ERCP is limited to only a bolus propofol dosing [16, 17].
This study was aimed to compare the differences in terms of recovery time, patients’ satisfaction, and sedation-related adverse events between conventional sedation (meperidine and midazolam), and cocktail regimen (meperidine, midazolam and continuously infused propofol) in patients undergoing ERCP.
Patients with suspected common bile duct stone(s) or distal common bile duct obstruction scheduled for ERCP during December 2006 to August 2009 at King Chulalongkorn Memorial hospital were recruited. Patients who were under 18 years old, pregnant; with American Society of Anesthesiologists’ (ASA) physical classification IV – V, with history of sulfite, egg or soy bean allergy, with emergency need for ERCP, those who informed consent could not be obtained, and those with possible complex ERCP (hilar cholangiocarcinoma, post Billroth II anatomy, etc. ) were excluded from this study. Verbal and written informed consent was obtained from all subjects. The randomization was done with a random sequence generated by a computer. Concealed envelop was broken when the patient was in the ERCP room. ERCP procedures were performed by an experienced endoscopist who performed 300–400 ERCPs annually for 10 years. The patients were put in a prone position during ERCP. The study protocol was approved by the Chulalongkorn Medical Institutional Review Board.
Sedation and monitorings
During the procedure, patients’ conscious level, unexpected movement, blood pressure, heart rate and oxygen saturation were monitored by an experienced endoscopy nurse under supervision of an advanced endoscopy fellow who certified in advanced cardiopulmonary life support. Blood pressure was measured by an automated blood pressure cuff every 5 minutes. Oxygen saturation and heart rate were monitored by a pulse oxymetry machine. Respiratory effort and respiratory rate were observed by visual inspection. All records were done at baseline, just before starting sedation, and every five minutes thereafter until patient had a full recovery. When desaturation or apnea developed between the 5-minute interval, those parameters were additionally noted. Sedation was maintained at the level of moderate (purposeful response to verbal or tactile stimulation) to deep sedation (purposeful response to repeated or painful stimulation). The oxygen supplementation was given only when patients’ oxygen saturation dropped to less than 90% and lasted for more than 10 seconds. Resuscitation equipments, flumazenil and naloxone were available in the endoscopy unit.
After the procedure, patients were monitored for recovery scores (modified Aldrete score) . Recovery scores were calculated at every 15 minutes. Time to full recovery was noted as the interval of 15 minutes. During the first 15 min, a nurse monitored patient closely at bedside and the exact time of full recovery in patients with fast recovery was noted.
Outcome measurements and definitions
The nurses in the recovery room were blinded for type of sedation. The procedure-related time included (1) induction time (the time from sedation to scope intubation), (2) procedural time (the time from scope intubation to scope withdrawal), and (3) recovery time (the time from scope withdrawal to full recovery (modified Aldrete score of 10)). The induction time and procedural time were recorded by the nurse in the endoscopy unit. The recovery time was recorded by the nurse in the recovery room.
Cardiopulmonary complications included (1) hypotension (systolic blood pressure drops to less than 90 mmHg or decreases more than 25% from the baseline), (2) bradycardia (heart rate <50 beats/min), (3) desaturation (oxygen saturation <90% for >10 seconds), and (4) apnea (cessation of respiratory activity for over 10 seconds under visual observation). If the oxygen saturation dropped to <85% for more than 30 seconds despite oxygen supplementation or apnea occurred, the procedure would be interrupted and reversal medications would be given to the patient.
Endoscopic nurse who well trained in propofol administration, administered medications and continuously monitored patients in both groups under supervision of an advanced endoscopy fellow who certified in advanced cardiac life support. All dosages were adopted from our previous publication  and our previous experience in using these agents. For induction, 25 mg of meperidine and 2.5 mg of midazolam were administered in both groups. In the cocktail group, one milligram per kilogram body weight of 1% propofol emulsion (Baxter Healthcare Corp., Irvine, CA) was slowly infused by an automated pump (Terufusion syringe pump TE-331, Terumo Corporation, Tokyo, Japan). To maintain conscious level of patient in the conventional group to be at moderate or deep level, 25 mg of meperidine and/or 2.5 mg of midazolam were administered as necessary, whereas patients in the cocktail group were continuously administered with 1% propofol at the rate of 1 mg/kg/hr. An additional 0.5 mg/kg bolus was administered as needed to achieve the designed conscious level.
After patients gained a full level of consciousness, the independent nurse in recovery room who blinded to the randomization assessed patients’ discomfort, gagging, and satisfaction by using a visual analogue scale (VAS). The VAS range from 0–100 for discomfort (0: none;100 worst discomfort imaginable, gagging (0: none; 100: worst gagging imaginable), and satisfaction (0: not satisfied at all; 100: completely satisfied).
Sample sizes were calculated based on mean and standard deviation of recovery times in the convention groups according to the results from our previous study; 34.25 minutes and 16.06, respectively . To determine the difference by two sided test with type I error of 0.05, power of 85%, 20% reduction of recovery time, and the ratio of study to control groups of 1, 100 subjects were needed from each groups.
Continuous outcomes with normal distribution were analyzed with independent 2 sample t-test, and Wilcoxon sum rank test was used to analyze nonparametric data. Categorical outcomes were analyzed with Chi-square or Fisher’s exact test where appropriate. Reported P value was 2-sided, with value of ≤ 0.05 considered statistically significant. The SPSS software version 16.0 (SPSS Inc., Chicago, IL, USA) was used to analyzed the outcome.
Patient and procedural variables
Age (years) a
57.27 ± 14.52
59.56 ± 13.65
Type of ERCP
22.18 ± 3.62
23.06 ± 3.83
Mean dosage (mg) a
58.33 ± 24.46
6.81 ± 2.12
172.08 ± 92.15
Dosage (mg/kg/hr) a
2.42 ± 2.58
1.06 ± 0.60
0.29 ± 0.36
0.11 ± 0.06
6.18 ± 3.0
Indications for ERCP
- CBD stone
- Benign biliary stricture
- Malignant biliary stricture
- Pancreatic therapy
Time to intubation (min) a
3.10 ± 1.86
3.68 ± 2.38
Duration (min) a
31.60 ± 17.56
Cardiovascular and respiratory parameters
Cardiovascular and respiratory parameters
Baseline SBP (mmHg)a
137.2 ± 22.1
134.2 ± 19.1
Mean% decrease of SBPa from baseline
16.0 ± 10.5
17.2 ± 11.9
SBP decrease ≥25% from baseline (% of patients)
SBP <90 mmHg (% of patients)
Baseline heart rate (HR/min) a
86.0 ± 14.8
85.7 ± 15.1
Mean% decrease of HR from baseline a
12.5 ± 11.3
14.1 ± 12.3
HR decrease ≥25% from baseline (% of patients)
Bradycardia (% of patients)
Baseline SpO2 (%)a
98.5 ± 1.5
97.8 ± 2.9
Greatest decline of SpO2 from baseline a
6.7 ± 6.1
8.7 ± 6.9
SpO2 <90% (% of patients, any episodes)
SpO2 <85% (% of patients, any episodes)
Recovery, patient tolerance and satisfaction
Recovery time (min)
12.89 ± 12.87
9.67 ± 4.86
Conscious score at 15 min
9.73 ± 0.45
9.85 ± 0.53
Conscious score at 30 min
9.95 ± 0.21
9.99 ± 0.10
Conscious score at 45 min
9.99 ± 0.11
10.00 ± 0.00
Conscious score at 60 min
9.99 ± 0.11
10.00 ± 0.00
Patient tolerance and satisfaction
Discomfort (Median; inter-quartile)
10 (10, 20)
10 (0, 20)
Gagging (Median; inter-quartile)
10 (10, 20)
10 (0, 20)
87.6 ± 9.6
93.1 ± 9.1
Over the last decade, we have seen an increase in propofol use for sedation in many GI endoscopies [2, 3]. The most important advantage of this agent is its fast recovery profile. In addition, non-anesthetists are able to give this agent. However, its narrow therapeutic window with a possible risk of apnea is the main concern. Thus, adequate experience of those who can administer this agent and early detection of overdosing skill are mandatory for patients’ safety. Propofol sedation at a moderate level is safe and well accepted for many diagnostic GI procedures [1–3]. However, the risk will increase if the level of conscious sedation is designed at moderate to deep sedation. Practically, this level of sedation is preferred for ERCP sedation. Our study confirmed the benefit of cocktail sedation containing propofol infusion over the conventional sedation in many categories including recovery profiles, patients’ tolerance, and satisfaction. Another hypothetical benefit in the present study was decreasing the rate of desaturation by reducing propofol dosage. We hypothesized that by giving continuous perfusion of propofol, the constant level of propofol would not exceed the therapeutic window and this in turn might result in an acceptable desaturation rate that comparable to the conventional sedation. Although, the dosage of proposal used in this study was lower than that of propofol infusion alone in the same population reported by us previously (6.2 mg/kg/hr vs. 9.4 mg.kg.hr) . Unfortunately, the present study failed to demonstrate the lower incidence of desaturation of this regimen over the conventional sedation. We observed a higher percentage of desaturation in the cocktail group than the conventional group (SpO2 <90%; 58.3% vs. 31.4%, p <0.01 and SpO2 < 85%; 8.7% vs. 1.0%, p < 0.019). However, these desaturation episodes were very short and did not interfere the continuity of our ERCP procedures. It may be implicated that reducing the dose of propofol was not equivalent to decreasing the risk of oversedation. We speculate that there are some pitfalls in our study that require further investigation. First, prophylactic oxygen supplementation was not routinely given to any of our patients. During the study period, all desaturated patients recovered immediately after oxygen cannula was given and only 2 L/min was required. There was no need for assisted ventilation in any patients. Other previous studies that gave a routine oxygen supplementation showed a lower rate of desaturation in the propofol group (5-24%) [12, 13, 17]. A prophylactic oxygen supplementation may apply to prevent this adverse event , however its discriminate use may expose patients to delays in the diagnosis of disventilation by maintaining apneic oxygenation during hypoventilation . Second, meperidine as the choice of narcotic agent in this study may result in a higher rate of desaturation than other short acting and milder narcotic agents such as pentazocine and fentanyl. Pentazocine is a synthetic narcotic that designed to have a lower rate of respiratory suppression . Ong, et al. used a combination of pentazocine and propofol for sedation in ERCP patients . They demonstrated a lower rate of desaturation (<5%) than ours. In addition, fentanyl is another narcotic with shorter half-life than meperidine. When compared with conventional sedation, a combination of propofol and fentanyl resulted in a faster recovery with similar safety even when these combinations were given in cirrhotic patients who underwent upper GI endoscopy . Lastly, hypercapnia usually develops before desaturation occurs . If we have used capnography in our study, we might have detected earlier cases of propofol overdose and desaturation rate might have been lower. Qadeer, et al. demonstrated that capnography is helpful for a better detection of apnic episode when compared with visual respiratory observation as confirmed by a lower hypoxic rate in the patients who underwent ERCP/EUS with capnography on board .
Cardiovascular adverse event related to propofol based sedation is another concern in non-anesthetist administered technique. Although, we observed a higher rate of dropping in systolic blood pressure to less than 90 mmHg in the cocktail group than the conventional group (14% vs. 5%), this rate of hypotension was not statistically significant and still comparable to the previous studies (13%) [5, 6]. Fortunately, these hypotensive episodes did not lead to any significant clinical cardiovascular compromise. We speculate that, histamine release causing hypotension can occur after a rapid administration of meperidine . Propofol itself can also cause hypotesion by relaxing vascular smooth muscle . Thus, the combined hypotensive effect may be potent especially during the initial phase of sedation. Alternatively, cocktail sedation containing fentanyl may cause a lower rate of hypotensive effect since fentanyl does not cause an over-release of histamine. However, further comparison study is required to confirm this hypothesis.
One of the limitations is that the level of sedation on each patient was controlled by a sedation nurse who was unblinded to sedative agents. Perhaps, there might be a bias in giving sedative agents at the doses that she preferred to be safe. However, this was more practical to real life practice since the level of sedation must be adjusted to the interest of patient safety as the first priority.
Although, we observed that the recovery time in the present conventional group (12.89 ± 12.87 minutes) seemed to be shorter than previous studies including our previous study (29–70 minutes) [4–6, 10, 25], the present study showed that the recovery time in the cocktail group was still significantly faster than the conventional group (9.67 ± 4.86 minutes vs. 12.89 ± 12.87 minutes, p = 0.045).We speculate that the overall shorter in procedural time was because of only non-complex ERCP such as common bile duct stone and distal common bile duct obstruction were recruited in the study. The low level of complexity in this seires was confirmed by a very low number of failed ERCP in both groups (0-2%).
Our patients in the cocktail group reported a significant higher satisfaction score than the patients in the conventional group (93 vs. 88, p < 0.001). The result was in line with a study by Lee, et al. that showed a non-significantly better satisfaction by patients when cocktail regimen was used for ERCP . Moreover, their study demonstrated a significantly better satisfaction by both endoscopists /nurses when propofol was used for sedation. During our study, we did not encounter any undesirable movement that would interfere the procedure outcome or delay the procedure time of any of the patients from both groups. However, the limitation in our study is that our protocol did not have a formal intra-procedural assessment by sedation team. Therefore, a complete evaluation of patients’ cooperation may not be assessed from this study.
In conclusion, the present study shows the superiority of cocktail sedation containing propofol infusion, midazolam, and meperidine over conventional sedation in terms of recovery profiles, patients’ tolerance, and satisfaction. Although there was no serious adverse event in the cocktail group, the results of the study actually showed the cocktail sedation increased the rate of desaturation, which implicated that reducing the dose of propofol in this cocktail protocol was not equivalent to decreasing the risk of oversedation. Adjustment in the protocol that may overcome this problem is required. We propose on using fentanyl or pentazocine instead of meperidine in the regime. Lastly, a prophylactic oxygen supplementation and monitoring with capnography may be of help.
The authors thank Dr. Sombat Treeprasertsuk for his comment on statistical analysis and all assistances in endoscopy suites in taking care of patients during the procedure.
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